A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes an RNA-binding protein ORF57 in lytic infection. Using an optimized CLIP-seq in this report, we identified ORF57-bound transcripts from 544 host protein-coding genes. By comparing with the RNA-seq profiles from BCBL-1 cells with latent...

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Main Authors: Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
Subjects:
KSHV
ORF57
RNA-binding protein
RNA stability
transcription factor FOS
Online Access:https://journals.asm.org/doi/10.1128/mbio.03172-24
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https://journals.asm.org/doi/10.1128/mbio.03172-24

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