Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008
Objective To determine the association between cataract surgery and age-related macular degeneration (AMD) in a representative US sample.Design Population-based, cross-sectional study.Setting The US National Health and Nutrition Examination Survey 2005–2008.Participants A total of 5401 participants...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e032745.full |
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| author | Jian Zhang Wei Wang Stuart Keel Mingguang He Zhuoting Zhu Huan Liao |
| author_facet | Jian Zhang Wei Wang Stuart Keel Mingguang He Zhuoting Zhu Huan Liao |
| author_sort | Jian Zhang |
| collection | DOAJ |
| description | Objective To determine the association between cataract surgery and age-related macular degeneration (AMD) in a representative US sample.Design Population-based, cross-sectional study.Setting The US National Health and Nutrition Examination Survey 2005–2008.Participants A total of 5401 participants aged ≥40 years had information in cataract surgery status and gradable retinal photographs for right eyes.Methods Cataract surgery status was obtained from questionnaire. Non-mydriatic fundus photographs were collected and AMD status was assessed. The associations between AMD and cataract surgery were evaluated in right eyes using logistic regression models.Results Of 338 right eyes with any AMD, 107 right eyes (28.9%) had cataract surgery. After adjusting for multiple variables, there were significant associations between cataract surgery and any AMD (OR 1.36; 95% CI 1.03 to 1.81) or late AMD (OR 2.48; 95% CI 1.01 to 6.09). No significant association was found between cataract surgery and early AMD after adjusting for multiple covariates (OR 1.20; 95% CI 0.91 to 1.59).Conclusion Our results suggest that cataract surgery is associated with the presence of AMD, particularly for late AMD. Longitudinal studies investigating the risk and progression of AMD after cataract surgery are needed in the era of phacoemulsification. |
| format | Article |
| id | doaj-art-d1b9b42bcebe48a78f1bc8cec34dc1b3 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d1b9b42bcebe48a78f1bc8cec34dc1b32025-01-08T18:15:13ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-032745Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008Jian Zhang0Wei Wang1Stuart Keel2Mingguang He3Zhuoting Zhu4Huan Liao5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaHainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, Hainan Province, ChinaCentre for Eye Research, Melbourne University, East Melbourne, Victoria, AustraliaCentre for Eye Research, Melbourne University, East Melbourne, Victoria, Australia1 Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People`s Hospital, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China5 University of Melbourne, Melbourne, Victoria, AustraliaObjective To determine the association between cataract surgery and age-related macular degeneration (AMD) in a representative US sample.Design Population-based, cross-sectional study.Setting The US National Health and Nutrition Examination Survey 2005–2008.Participants A total of 5401 participants aged ≥40 years had information in cataract surgery status and gradable retinal photographs for right eyes.Methods Cataract surgery status was obtained from questionnaire. Non-mydriatic fundus photographs were collected and AMD status was assessed. The associations between AMD and cataract surgery were evaluated in right eyes using logistic regression models.Results Of 338 right eyes with any AMD, 107 right eyes (28.9%) had cataract surgery. After adjusting for multiple variables, there were significant associations between cataract surgery and any AMD (OR 1.36; 95% CI 1.03 to 1.81) or late AMD (OR 2.48; 95% CI 1.01 to 6.09). No significant association was found between cataract surgery and early AMD after adjusting for multiple covariates (OR 1.20; 95% CI 0.91 to 1.59).Conclusion Our results suggest that cataract surgery is associated with the presence of AMD, particularly for late AMD. Longitudinal studies investigating the risk and progression of AMD after cataract surgery are needed in the era of phacoemulsification.https://bmjopen.bmj.com/content/10/9/e032745.full |
| spellingShingle | Jian Zhang Wei Wang Stuart Keel Mingguang He Zhuoting Zhu Huan Liao Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008 BMJ Open |
| title | Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008 |
| title_full | Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008 |
| title_fullStr | Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008 |
| title_full_unstemmed | Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008 |
| title_short | Cross-sectional study of the association between cataract surgery and age-related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005–2008 |
| title_sort | cross sectional study of the association between cataract surgery and age related macular degeneration in the era of phacoemulsification in the national health and nutrition examination survey 2005 2008 |
| url | https://bmjopen.bmj.com/content/10/9/e032745.full |
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