GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma

Background A better understanding of the molecular mechanisms that manifest in the immunosuppressive tumor microenvironment (TME) is crucial for developing more efficacious immunotherapies for hepatocellular carcinoma (HCC), which has a poor response to current immunotherapies. Regulatory T (Treg) c...

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Main Authors: Meng Li, Yuan Gao, Wei Zhang, Zhijun Tan, Kuo Zhang, Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Qiang Hao, Wangqian Zhang, Shuning Wang, Jintao Gu, Lei Shang, Haichuan Su, Yingqi Zhang, Cun Zhang
Format: Article
Language:English
Published: BMJ Publishing Group 2021-09-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/9/e002787.full
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