Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans

Alzheimer's disease (AD) is a neurodegenerative ailment that is becoming increasingly common, making it a major worldwide health concern. Effective care depends on an early and correct diagnosis, but traditional diagnostic techniques are frequently constrained by subjectivity and expensive cost...

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Main Authors: Zhen Zhao, Pauline Shan Qing Yeoh, Xiaowei Zuo, Joon Huang Chuah, Chee-Onn Chow, Xiang Wu, Khin Wee Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Neurology
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Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1490829/full
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author Zhen Zhao
Pauline Shan Qing Yeoh
Xiaowei Zuo
Joon Huang Chuah
Chee-Onn Chow
Xiang Wu
Khin Wee Lai
author_facet Zhen Zhao
Pauline Shan Qing Yeoh
Xiaowei Zuo
Joon Huang Chuah
Chee-Onn Chow
Xiang Wu
Khin Wee Lai
author_sort Zhen Zhao
collection DOAJ
description Alzheimer's disease (AD) is a neurodegenerative ailment that is becoming increasingly common, making it a major worldwide health concern. Effective care depends on an early and correct diagnosis, but traditional diagnostic techniques are frequently constrained by subjectivity and expensive costs. This study proposes a novel Vision Transformer-equipped Convolutional Neural Networks (VECNN) that uses three-dimensional magnetic resonance imaging to improve diagnosis accuracy. Utilizing the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, which comprised 2,248 3D MRI images and diverse patient demographics, the proposed model achieved an accuracy of 92.14%, a precision of 86.84%, a sensitivity of 93.27%, and a specificity of 89.95% in distinguishing between AD, healthy controls (HC), and moderate cognitive impairment (MCI). The findings suggest that VECNN can be a valuable tool in clinical settings, providing a non-invasive, cost-effective, and objective diagnostic technique. This research opens the door for future advancements in early diagnosis and personalized therapy for Alzheimer's Disease.
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institution Kabale University
issn 1664-2295
language English
publishDate 2024-12-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Neurology
spelling doaj-art-d1b3d8757a57456794b1a9d07d89aadd2024-12-16T05:10:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.14908291490829Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scansZhen Zhao0Pauline Shan Qing Yeoh1Xiaowei Zuo2Joon Huang Chuah3Chee-Onn Chow4Xiang Wu5Khin Wee Lai6Department of Electrical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Psychiatry, The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Electrical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Electrical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, MalaysiaSchool of Medical Information Engineering, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, MalaysiaAlzheimer's disease (AD) is a neurodegenerative ailment that is becoming increasingly common, making it a major worldwide health concern. Effective care depends on an early and correct diagnosis, but traditional diagnostic techniques are frequently constrained by subjectivity and expensive costs. This study proposes a novel Vision Transformer-equipped Convolutional Neural Networks (VECNN) that uses three-dimensional magnetic resonance imaging to improve diagnosis accuracy. Utilizing the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, which comprised 2,248 3D MRI images and diverse patient demographics, the proposed model achieved an accuracy of 92.14%, a precision of 86.84%, a sensitivity of 93.27%, and a specificity of 89.95% in distinguishing between AD, healthy controls (HC), and moderate cognitive impairment (MCI). The findings suggest that VECNN can be a valuable tool in clinical settings, providing a non-invasive, cost-effective, and objective diagnostic technique. This research opens the door for future advancements in early diagnosis and personalized therapy for Alzheimer's Disease.https://www.frontiersin.org/articles/10.3389/fneur.2024.1490829/fullAlzheimer's diseaseclassificationConvolutional Neural Networkmagnetic resonance imagingtransformer
spellingShingle Zhen Zhao
Pauline Shan Qing Yeoh
Xiaowei Zuo
Joon Huang Chuah
Chee-Onn Chow
Xiang Wu
Khin Wee Lai
Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans
Frontiers in Neurology
Alzheimer's disease
classification
Convolutional Neural Network
magnetic resonance imaging
transformer
title Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans
title_full Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans
title_fullStr Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans
title_full_unstemmed Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans
title_short Vision transformer-equipped Convolutional Neural Networks for automated Alzheimer's disease diagnosis using 3D MRI scans
title_sort vision transformer equipped convolutional neural networks for automated alzheimer s disease diagnosis using 3d mri scans
topic Alzheimer's disease
classification
Convolutional Neural Network
magnetic resonance imaging
transformer
url https://www.frontiersin.org/articles/10.3389/fneur.2024.1490829/full
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