Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis
Background Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preeclampsia/eclampsia, the causal relationship remains unclear. The aim of this study was to inv...
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Taylor & Francis Group
2024-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2024.2321148 |
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| author | Xiaofeng Yang Jiachun Wei Lu Sun Qimei Zhong Xiaoxuan Zhai Ya Chen Shujuan Luo Chunyan Tang Lan Wang |
| author_facet | Xiaofeng Yang Jiachun Wei Lu Sun Qimei Zhong Xiaoxuan Zhai Ya Chen Shujuan Luo Chunyan Tang Lan Wang |
| author_sort | Xiaofeng Yang |
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| description | Background Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preeclampsia/eclampsia, the causal relationship remains unclear. The aim of this study was to investigate the genetic causality between iron status and preeclampsia/eclampsia using large-scale genome-wide association study (GWAS) summary data and Mendelian randomization (MR) analysis.Methods Summary data for the GWAS on preeclampsia/eclampsia and genetic markers related to iron status were obtained from the FinnGen Consortium and the IEU genetic databases. The “TwoSampleMR” software package in R was employed to test the genetic causality between these markers and preeclampsia/eclampsia. The inverse variance weighted (IVW) method was primarily used for MR analysis. Heterogeneity, horizontal pleiotropy, and potential outliers were evaluated for the MR analysis results.Results The random-effects IVW results showed that ferritin (OR = 1.11, 95% CI: .89–1.38, p = .341), serum iron (OR = .90, 95% CI: .75–1.09, p = .275), TIBC (OR = .98, 95% CI: .89–1.07, p = .613), and TSAT (OR = .94, 95% CI: .83–1.07, p = .354) have no genetic causal relationship with preeclampsia/eclampsia. There was no evidence of heterogeneity, horizontal pleiotropy, or possible outliers in our MR analysis (p > .05).Conclusions Our study did not detect a genetic causal relationship between iron status and preeclampsia/eclampsia. Nonetheless, this does not rule out a relationship between the two at other mechanistic levels. |
| format | Article |
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| institution | Kabale University |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-d1ae6c5ea0954813b0a397b2d7c1c21f2024-12-16T03:46:05ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062024-12-0146110.1080/10641963.2024.2321148Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysisXiaofeng Yang0Jiachun Wei1Lu Sun2Qimei Zhong3Xiaoxuan Zhai4Ya Chen5Shujuan Luo6Chunyan Tang7Lan Wang8Department of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, Chongqing, ChinaBackground Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preeclampsia/eclampsia, the causal relationship remains unclear. The aim of this study was to investigate the genetic causality between iron status and preeclampsia/eclampsia using large-scale genome-wide association study (GWAS) summary data and Mendelian randomization (MR) analysis.Methods Summary data for the GWAS on preeclampsia/eclampsia and genetic markers related to iron status were obtained from the FinnGen Consortium and the IEU genetic databases. The “TwoSampleMR” software package in R was employed to test the genetic causality between these markers and preeclampsia/eclampsia. The inverse variance weighted (IVW) method was primarily used for MR analysis. Heterogeneity, horizontal pleiotropy, and potential outliers were evaluated for the MR analysis results.Results The random-effects IVW results showed that ferritin (OR = 1.11, 95% CI: .89–1.38, p = .341), serum iron (OR = .90, 95% CI: .75–1.09, p = .275), TIBC (OR = .98, 95% CI: .89–1.07, p = .613), and TSAT (OR = .94, 95% CI: .83–1.07, p = .354) have no genetic causal relationship with preeclampsia/eclampsia. There was no evidence of heterogeneity, horizontal pleiotropy, or possible outliers in our MR analysis (p > .05).Conclusions Our study did not detect a genetic causal relationship between iron status and preeclampsia/eclampsia. Nonetheless, this does not rule out a relationship between the two at other mechanistic levels.https://www.tandfonline.com/doi/10.1080/10641963.2024.2321148Mendelian randomizationiron statuspreeclampsiacausal relationshipgenetic variants |
| spellingShingle | Xiaofeng Yang Jiachun Wei Lu Sun Qimei Zhong Xiaoxuan Zhai Ya Chen Shujuan Luo Chunyan Tang Lan Wang Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis Clinical and Experimental Hypertension Mendelian randomization iron status preeclampsia causal relationship genetic variants |
| title | Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis |
| title_full | Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis |
| title_fullStr | Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis |
| title_full_unstemmed | Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis |
| title_short | Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis |
| title_sort | causal relationship between iron status and preeclampsia eclampsia a mendelian randomization analysis |
| topic | Mendelian randomization iron status preeclampsia causal relationship genetic variants |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2024.2321148 |
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