Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients
Metabolites and antioxidants can be altered in patients with various diseases, particularly in those with cancer. This study aims to measure melatonin and total antioxidant levels in the serum of breast cancer patients and compare them with a healthy control group. Both groups had serum samples coll...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
QAASPA Publisher
2024-06-01
|
| Series: | BioMed Target Journal |
| Subjects: | |
| Online Access: | https://qaaspa.com/index.php/bmtj/article/view/19 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841546238379425792 |
|---|---|
| author | Amjad Mahmood Qadir Arzu Karatepe Ayşegül Yazici Rzgar Farooq Rashid Pelin Koparir Rebaz A. Omer Shamal R. Hama |
| author_facet | Amjad Mahmood Qadir Arzu Karatepe Ayşegül Yazici Rzgar Farooq Rashid Pelin Koparir Rebaz A. Omer Shamal R. Hama |
| author_sort | Amjad Mahmood Qadir |
| collection | DOAJ |
| description | Metabolites and antioxidants can be altered in patients with various diseases, particularly in those with cancer. This study aims to measure melatonin and total antioxidant levels in the serum of breast cancer patients and compare them with a healthy control group. Both groups had serum samples collected at 2:00 a.m. and 9:00 a.m. Melatonin levels were determined using High-performance liquid chromatography (HPLC), while total antioxidant levels were assessed by Enzyme-linked immunosorbent assay (ELISA). Levels of melatonin and total antioxidants differed between the groups. In the control group, the levels of melatonin and total antioxidants were considerably greater compared to the diagnostic group, with a p-value of 0.001. Melatonin and total antioxidant levels were consistently greater at 2:00 than at 9:00. The maximum melatonin levels recorded in the diagnostic and control groups were 39.3 pg/mL and 65.9 pg/mL, respectively. Melatonin levels varied based on the age of the participants, with higher amounts observed in younger participants compared to older people in both groups. The BMI affected the levels of melatonin, with a greater BMI leading to elevated melatonin concentrations. The diagnostic group had a total antioxidant level of 39.3 pg/mL, while the control group had a level of 65.9 pg/mL. The elevated levels of melatonin and total antioxidants in the control group indicate a healthy status. The research demonstrated a significant correlation between melatonin and antioxidant levels in breast cancer patients, with reduced melatonin levels and total antioxidant levels in the diagnosed group. Elevated BMI was linked to reduced melatonin levels. |
| format | Article |
| id | doaj-art-d178ceec49b64d91b0492bc2484af01d |
| institution | Kabale University |
| issn | 2960-1428 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | QAASPA Publisher |
| record_format | Article |
| series | BioMed Target Journal |
| spelling | doaj-art-d178ceec49b64d91b0492bc2484af01d2025-01-10T21:54:26ZengQAASPA PublisherBioMed Target Journal2960-14282024-06-0121354210.59786/bmtj.21519Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer PatientsAmjad Mahmood Qadir0https://orcid.org/0000-0002-4142-6118Arzu Karatepe1https://orcid.org/0000-0001-6649-2130Ayşegül Yazici2https://orcid.org/0000-0001-7150-9849Rzgar Farooq Rashid3https://orcid.org/0000-0002-0846-9888Pelin Koparir4https://orcid.org/0000-0002-3981-9748Rebaz A. Omer5https://orcid.org/0000-0001-7468-516XShamal R. Hama6https://orcid.org/0000-0001-6837-4891Department of General Science, College of Basic Education, University of Halabja, Halabja, 46018, IraqDepartment of Chemistry, Faculty of Science, Bingol University, Bingol, 12000, TurkeyDepartment of Inorganic Chemistry, College of Science, Firat University, Elazig, 23169, TurkeyDepartment of Medical Laboratory Science, College of Science, Knowledge University, Erbil, 44001, IraqDepartment of Chemistry, College of Science, Firat University, Elazig, 23169, TurkeyDepartment of Chemistry, Faculty of Science & Health, Koya University, Koya KOY45, IraqResearch Office, IRO, University of Halabja, Halabja, 46018, IraqMetabolites and antioxidants can be altered in patients with various diseases, particularly in those with cancer. This study aims to measure melatonin and total antioxidant levels in the serum of breast cancer patients and compare them with a healthy control group. Both groups had serum samples collected at 2:00 a.m. and 9:00 a.m. Melatonin levels were determined using High-performance liquid chromatography (HPLC), while total antioxidant levels were assessed by Enzyme-linked immunosorbent assay (ELISA). Levels of melatonin and total antioxidants differed between the groups. In the control group, the levels of melatonin and total antioxidants were considerably greater compared to the diagnostic group, with a p-value of 0.001. Melatonin and total antioxidant levels were consistently greater at 2:00 than at 9:00. The maximum melatonin levels recorded in the diagnostic and control groups were 39.3 pg/mL and 65.9 pg/mL, respectively. Melatonin levels varied based on the age of the participants, with higher amounts observed in younger participants compared to older people in both groups. The BMI affected the levels of melatonin, with a greater BMI leading to elevated melatonin concentrations. The diagnostic group had a total antioxidant level of 39.3 pg/mL, while the control group had a level of 65.9 pg/mL. The elevated levels of melatonin and total antioxidants in the control group indicate a healthy status. The research demonstrated a significant correlation between melatonin and antioxidant levels in breast cancer patients, with reduced melatonin levels and total antioxidant levels in the diagnosed group. Elevated BMI was linked to reduced melatonin levels.https://qaaspa.com/index.php/bmtj/article/view/19breast cancerhplcelisamelatonintotal antioxidantssleeping disorder |
| spellingShingle | Amjad Mahmood Qadir Arzu Karatepe Ayşegül Yazici Rzgar Farooq Rashid Pelin Koparir Rebaz A. Omer Shamal R. Hama Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients BioMed Target Journal breast cancer hplc elisa melatonin total antioxidants sleeping disorder |
| title | Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients |
| title_full | Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients |
| title_fullStr | Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients |
| title_full_unstemmed | Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients |
| title_short | Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients |
| title_sort | evaluation of melatonin and antioxidant levels in the serum of breast cancer patients |
| topic | breast cancer hplc elisa melatonin total antioxidants sleeping disorder |
| url | https://qaaspa.com/index.php/bmtj/article/view/19 |
| work_keys_str_mv | AT amjadmahmoodqadir evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients AT arzukaratepe evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients AT aysegulyazici evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients AT rzgarfarooqrashid evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients AT pelinkoparir evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients AT rebazaomer evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients AT shamalrhama evaluationofmelatoninandantioxidantlevelsintheserumofbreastcancerpatients |