Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan
Objectives This study aimed to determine if treatment delay after non-small cell lung cancer (NSCLC) diagnosis impacts patient survival rate.Study design This study is a natural experiment in Taiwan. A retrospective cohort investigation was conducted from 2004 to 2010, which included 42 962 patients...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/4/e034351.full |
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| _version_ | 1846142153522151424 |
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| author | Pei-Tseng Kung Wen-Chen Tsai Chang-Hung Tsai Wei-Yin Kuo |
| author_facet | Pei-Tseng Kung Wen-Chen Tsai Chang-Hung Tsai Wei-Yin Kuo |
| author_sort | Pei-Tseng Kung |
| collection | DOAJ |
| description | Objectives This study aimed to determine if treatment delay after non-small cell lung cancer (NSCLC) diagnosis impacts patient survival rate.Study design This study is a natural experiment in Taiwan. A retrospective cohort investigation was conducted from 2004 to 2010, which included 42 962 patients with newly diagnosed NSCLC.Methods We identified 42 962 patients with newly diagnosed NSCLC in the Taiwan Cancer Registry from 2004 to 2010. We calculated the time interval between diagnosis and treatment initiation. All patients were followed from the index date to death or the end of 2012. Cox proportional hazard models were used to examine the relationship between mortality and time interval.Results We included 42 962 patients (15 799 men and 27 163 women) with newly diagnosed NSCLC. The mortality rate exhibited a significantly positive correlation to time interval from cancer diagnosis to treatment initiation. The adjusted HRs ranged from 1.04 to 1.08 in all subgroups time interval more than 7 days compared with the counterpart subgroup of the interval from cancer diagnosis to treatment ≤7 days. The trend was also noted regardless of the patients with lung cancer in stage I, stage II and stage III.Conclusions There is a major association between time to treat and mortality of patients with NSCLC, especially in stages I and II. We suggest that efforts should be made to minimise the interval from diagnosis to treatment while further study is ongoing to determine causation. |
| format | Article |
| id | doaj-art-d1761e5b1b6d411f9eebb689f410085d |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d1761e5b1b6d411f9eebb689f410085d2024-12-03T17:10:13ZengBMJ Publishing GroupBMJ Open2044-60552020-04-0110410.1136/bmjopen-2019-034351Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in TaiwanPei-Tseng Kung0Wen-Chen Tsai1Chang-Hung Tsai2Wei-Yin Kuo3Department of Healthcare Administration, Asia University, Taichung, TaiwanDepartment of Health Services Administration, China Medical University, Taichung, TaiwanDepartment of Public Health, China Medical University, Taichung, TaiwanDepartment of Health Services Administration, China Medical University, Taichung, TaiwanObjectives This study aimed to determine if treatment delay after non-small cell lung cancer (NSCLC) diagnosis impacts patient survival rate.Study design This study is a natural experiment in Taiwan. A retrospective cohort investigation was conducted from 2004 to 2010, which included 42 962 patients with newly diagnosed NSCLC.Methods We identified 42 962 patients with newly diagnosed NSCLC in the Taiwan Cancer Registry from 2004 to 2010. We calculated the time interval between diagnosis and treatment initiation. All patients were followed from the index date to death or the end of 2012. Cox proportional hazard models were used to examine the relationship between mortality and time interval.Results We included 42 962 patients (15 799 men and 27 163 women) with newly diagnosed NSCLC. The mortality rate exhibited a significantly positive correlation to time interval from cancer diagnosis to treatment initiation. The adjusted HRs ranged from 1.04 to 1.08 in all subgroups time interval more than 7 days compared with the counterpart subgroup of the interval from cancer diagnosis to treatment ≤7 days. The trend was also noted regardless of the patients with lung cancer in stage I, stage II and stage III.Conclusions There is a major association between time to treat and mortality of patients with NSCLC, especially in stages I and II. We suggest that efforts should be made to minimise the interval from diagnosis to treatment while further study is ongoing to determine causation.https://bmjopen.bmj.com/content/10/4/e034351.full |
| spellingShingle | Pei-Tseng Kung Wen-Chen Tsai Chang-Hung Tsai Wei-Yin Kuo Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan BMJ Open |
| title | Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan |
| title_full | Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan |
| title_fullStr | Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan |
| title_full_unstemmed | Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan |
| title_short | Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan |
| title_sort | effect of time interval from diagnosis to treatment for non small cell lung cancer on survival a national cohort study in taiwan |
| url | https://bmjopen.bmj.com/content/10/4/e034351.full |
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