A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics

A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics

Abstract The current research investigated the development of a multi-epitope mRNA vaccine against the rabies virus on the basis of viral proteomes via the use of bioinformatic tools and reverse vaccinology. The aim of this study was to address the limitations of the currently available rabies vacci...

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Bibliographic Details
Main Authors: Wafa Tombari, Oussema Khamessi, Houcemeddine Othman, Ouafa Kallala, Rihab Mahjoub, Kais Ghedira, Abdelhalim Trabelsi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Rabies
MRNA-based multi-epitope vaccine
Epitope prediction
Immunoinformatics
Immune simulation
Molecular dynamics simulation
Online Access:https://doi.org/10.1038/s41598-025-16143-w
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