Telomerase-based vaccines: a promising frontier in cancer immunotherapy
Abstract Telomerase, an enzyme crucial for maintaining telomere length, plays a critical role in cellular immortality and is overexpressed in most cancers. This ubiquitous presence makes telomerase, and specifically its catalytic subunit, human telomerase reverse transcriptase (hTERT), an attractive...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-024-03624-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846112148137181184 |
|---|---|
| author | Sogand Vahidi Arefeh Zabeti Touchaei |
| author_facet | Sogand Vahidi Arefeh Zabeti Touchaei |
| author_sort | Sogand Vahidi |
| collection | DOAJ |
| description | Abstract Telomerase, an enzyme crucial for maintaining telomere length, plays a critical role in cellular immortality and is overexpressed in most cancers. This ubiquitous presence makes telomerase, and specifically its catalytic subunit, human telomerase reverse transcriptase (hTERT), an attractive target for cancer immunotherapy. This review explores the development and application of telomerase-based vaccines, focusing on DNA and peptide-based approaches. While DNA vaccines demonstrate promising immunogenicity, peptide vaccines, such as UV1, UCPVax, and Vx-001, have shown clinical efficacy in certain cancer types. Recent advancements in vaccine design, including multiple peptides and adjuvants, have enhanced immune responses. However, challenges remain in achieving consistent and durable anti-tumor immunity. Accordingly, we discuss the mechanisms of action, preclinical and clinical data, and the potential of these vaccines to elicit robust and durable anti-tumor immune responses. This review highlights the potential of telomerase-based vaccines as a promising strategy for cancer treatment and identifies areas for future research. |
| format | Article |
| id | doaj-art-d160a306e56d456fb87f5f6a042b9660 |
| institution | Kabale University |
| issn | 1475-2867 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-d160a306e56d456fb87f5f6a042b96602024-12-22T12:49:03ZengBMCCancer Cell International1475-28672024-12-0124111710.1186/s12935-024-03624-7Telomerase-based vaccines: a promising frontier in cancer immunotherapySogand Vahidi0Arefeh Zabeti Touchaei1Medical Biology Research Center, Kermanshah University of Medical SciencesDepartment of Chemistry, Lahijan Branch, Islamic Azad UniversityAbstract Telomerase, an enzyme crucial for maintaining telomere length, plays a critical role in cellular immortality and is overexpressed in most cancers. This ubiquitous presence makes telomerase, and specifically its catalytic subunit, human telomerase reverse transcriptase (hTERT), an attractive target for cancer immunotherapy. This review explores the development and application of telomerase-based vaccines, focusing on DNA and peptide-based approaches. While DNA vaccines demonstrate promising immunogenicity, peptide vaccines, such as UV1, UCPVax, and Vx-001, have shown clinical efficacy in certain cancer types. Recent advancements in vaccine design, including multiple peptides and adjuvants, have enhanced immune responses. However, challenges remain in achieving consistent and durable anti-tumor immunity. Accordingly, we discuss the mechanisms of action, preclinical and clinical data, and the potential of these vaccines to elicit robust and durable anti-tumor immune responses. This review highlights the potential of telomerase-based vaccines as a promising strategy for cancer treatment and identifies areas for future research.https://doi.org/10.1186/s12935-024-03624-7TelomeraseCancer immunotherapyDNA vaccinePeptide vaccinehTERT |
| spellingShingle | Sogand Vahidi Arefeh Zabeti Touchaei Telomerase-based vaccines: a promising frontier in cancer immunotherapy Cancer Cell International Telomerase Cancer immunotherapy DNA vaccine Peptide vaccine hTERT |
| title | Telomerase-based vaccines: a promising frontier in cancer immunotherapy |
| title_full | Telomerase-based vaccines: a promising frontier in cancer immunotherapy |
| title_fullStr | Telomerase-based vaccines: a promising frontier in cancer immunotherapy |
| title_full_unstemmed | Telomerase-based vaccines: a promising frontier in cancer immunotherapy |
| title_short | Telomerase-based vaccines: a promising frontier in cancer immunotherapy |
| title_sort | telomerase based vaccines a promising frontier in cancer immunotherapy |
| topic | Telomerase Cancer immunotherapy DNA vaccine Peptide vaccine hTERT |
| url | https://doi.org/10.1186/s12935-024-03624-7 |
| work_keys_str_mv | AT sogandvahidi telomerasebasedvaccinesapromisingfrontierincancerimmunotherapy AT arefehzabetitouchaei telomerasebasedvaccinesapromisingfrontierincancerimmunotherapy |