PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS
Aim. The research aims to study of the issue of pharmaceutical care of acne patients when using systemic retinoids. Materials and Methods. The following methods were used: systematic approach, bibliographic, questionnaire survey, statistical, pharmacoeconomic assessment. The objects of the study:...
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| Format: | Article |
| Language: | English |
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Danylo Halytsky Lviv National Medical University
2023-12-01
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| Series: | Acta Medica Leopoliensia |
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| Online Access: | https://amljournal.com/index.php/journal/article/view/367 |
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| _version_ | 1841557748707229696 |
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| author | Yuliya Nastyukha Andriy Zimenkovsky Diana Klapko |
| author_facet | Yuliya Nastyukha Andriy Zimenkovsky Diana Klapko |
| author_sort | Yuliya Nastyukha |
| collection | DOAJ |
| description | Aim. The research aims to study of the issue of pharmaceutical care of acne patients when using systemic retinoids.
Materials and Methods. The following methods were used: systematic approach, bibliographic, questionnaire survey, statistical, pharmacoeconomic assessment. The objects of the study: relevant information sources; current standards of pharmacotherapy, instructions for medical use of isotretinoin of the State Register of Medicines of Ukraine (n=4), 14th edition of the State Drug Formulary; questionnaires of acne patients who use systemic retinoids (n=53); pharmacy quotes for isotretinoin drugs and laboratory quotes for liver biopsy and lipid testing. The subject of the study: appropriate pharmaceutical care of acne patients when using systemic retinoids.
Results and Discussion. The results of the questionnaire showed that, despite high awareness, the practice of patients' compliance with the recommendations regarding the use of isotretinoin needs to be optimized, in particular by means of pharmaceutical care, which was provided in only 30.2% (95CI: 18.3-44.3%) cases according to the patients. As a result of the analysis of current regulatory-legal documents, 6 main guidelines were identified, including 10 key messages of pharmaceutical care. Considering the extremely low level of proper implementation of the Pregnancy Prevention Program when using systemic retinoids (3.7%; 95CI: 0.1-19.0%) and the severity of the consequences of neglecting the recommendations (teratogenic effect), pharmaceutical care should include the issue of effective contraception and pregnancy testing by not only informing but also finding and using other strategies to increase patient compliance with the recommendations, in our opinion. We consider that the discussion with the patient regarding the costs of pharmacotherapy with systemic retinoids (according to the results of our study - from ₴ 17919.20 to ₴ 25307.50), in addition to the cost of isotretinoin (from ₴ 15417.20 to ₴ 21550.00), should include the costs of conducting laboratory control of liver tests (from ₴ 1530.00 to ₴ 2340.00), lipidogram (from ₴ 972.00 to ₴ 1417.50) and meeting some other individual patient needs.
Conclusions. Studying the issue of pharmaceutical care when using systemic retinoids allowed to determine the main guidelines (n=6) and key messages (n=10) that pharmacists can focus on during professional communication with acne patients, which makes it possible to increase the effectiveness and safety of pharmacotherapy. |
| format | Article |
| id | doaj-art-d153a54e510345679507680ef9f4dcce |
| institution | Kabale University |
| issn | 1029-4244 2415-3303 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Danylo Halytsky Lviv National Medical University |
| record_format | Article |
| series | Acta Medica Leopoliensia |
| spelling | doaj-art-d153a54e510345679507680ef9f4dcce2025-01-06T10:49:52ZengDanylo Halytsky Lviv National Medical UniversityActa Medica Leopoliensia1029-42442415-33032023-12-01293-4799610.25040/aml2023.3-4.079367PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDSYuliya Nastyukha0Andriy Zimenkovsky1Diana Klapko2Danylo Halytsky Lviv National Medical University, city of Lviv, UkraineDanylo Halytsky Lviv National Medical University, city of Lviv, UkraineDanylo Halytsky Lviv National Medical University, city of Lviv, UkraineAim. The research aims to study of the issue of pharmaceutical care of acne patients when using systemic retinoids. Materials and Methods. The following methods were used: systematic approach, bibliographic, questionnaire survey, statistical, pharmacoeconomic assessment. The objects of the study: relevant information sources; current standards of pharmacotherapy, instructions for medical use of isotretinoin of the State Register of Medicines of Ukraine (n=4), 14th edition of the State Drug Formulary; questionnaires of acne patients who use systemic retinoids (n=53); pharmacy quotes for isotretinoin drugs and laboratory quotes for liver biopsy and lipid testing. The subject of the study: appropriate pharmaceutical care of acne patients when using systemic retinoids. Results and Discussion. The results of the questionnaire showed that, despite high awareness, the practice of patients' compliance with the recommendations regarding the use of isotretinoin needs to be optimized, in particular by means of pharmaceutical care, which was provided in only 30.2% (95CI: 18.3-44.3%) cases according to the patients. As a result of the analysis of current regulatory-legal documents, 6 main guidelines were identified, including 10 key messages of pharmaceutical care. Considering the extremely low level of proper implementation of the Pregnancy Prevention Program when using systemic retinoids (3.7%; 95CI: 0.1-19.0%) and the severity of the consequences of neglecting the recommendations (teratogenic effect), pharmaceutical care should include the issue of effective contraception and pregnancy testing by not only informing but also finding and using other strategies to increase patient compliance with the recommendations, in our opinion. We consider that the discussion with the patient regarding the costs of pharmacotherapy with systemic retinoids (according to the results of our study - from ₴ 17919.20 to ₴ 25307.50), in addition to the cost of isotretinoin (from ₴ 15417.20 to ₴ 21550.00), should include the costs of conducting laboratory control of liver tests (from ₴ 1530.00 to ₴ 2340.00), lipidogram (from ₴ 972.00 to ₴ 1417.50) and meeting some other individual patient needs. Conclusions. Studying the issue of pharmaceutical care when using systemic retinoids allowed to determine the main guidelines (n=6) and key messages (n=10) that pharmacists can focus on during professional communication with acne patients, which makes it possible to increase the effectiveness and safety of pharmacotherapy.https://amljournal.com/index.php/journal/article/view/367systemic retinoidsacnepharmaceutical care |
| spellingShingle | Yuliya Nastyukha Andriy Zimenkovsky Diana Klapko PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS Acta Medica Leopoliensia systemic retinoids acne pharmaceutical care |
| title | PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS |
| title_full | PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS |
| title_fullStr | PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS |
| title_full_unstemmed | PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS |
| title_short | PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS |
| title_sort | pharmaceutical care of acne patients using systemic retinoids |
| topic | systemic retinoids acne pharmaceutical care |
| url | https://amljournal.com/index.php/journal/article/view/367 |
| work_keys_str_mv | AT yuliyanastyukha pharmaceuticalcareofacnepatientsusingsystemicretinoids AT andriyzimenkovsky pharmaceuticalcareofacnepatientsusingsystemicretinoids AT dianaklapko pharmaceuticalcareofacnepatientsusingsystemicretinoids |