Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles
Background: A wide variety of studies demonstrate the influence of the oocyte source’s age on the success of assisted reproduction treatments; however, the effect of paternal age has been studied to a lesser extent. Therefore, our goal was to assess the impact of male age and sperm quality on in vit...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806222 |
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| author | Jeimy Pedraza Hugo Sierra Jacqueline Cordero Esther López-Bayghen |
| author_facet | Jeimy Pedraza Hugo Sierra Jacqueline Cordero Esther López-Bayghen |
| author_sort | Jeimy Pedraza |
| collection | DOAJ |
| description | Background: A wide variety of studies demonstrate the influence of the oocyte source’s age on the success of assisted reproduction treatments; however, the effect of paternal age has been studied to a lesser extent. Therefore, our goal was to assess the impact of male age and sperm quality on in vitro fertilization (IVF) outcomes. Methods: Three hundred ninety-four ova donation IVF cycles from Ingenes México were retrospectively analyzed. All ova donors (age range: 18–35 years) underwent a similar IVF stimulation protocol. The oocytes were aspirated and inseminated by intracytoplasmic sperm injection (ICSI) using either partner sperm (n = 332, age: 42.4 ± 7.4 years) or donor sperm (n = 62, age: 25.0 ± 3.3 years). Semen characteristics were evaluated by a seminogram. Biopsies were performed on Day 5 or Day 6, and Preimplantation Genetic Testing for Aneuploidies (PGT-A) was used to determine chromosome integrity with Next-Generation Sequencing. Results: A total of 1449 embryos were biopsied, 995 Day 5 and 454 Day 6. The aneuploidy rates for Day 5 and Day 6 embryos were not significantly different (22.2% and 22.7%, respectively). Independent of the sperm source, there was no observable trend between embryo aneuploidy rates and the sperm source’s age; however, when considering paternal sperm with teratozoospermia, a significant association was observed (rho = 0.165, p = 0.041). Sperm quality showed no effect on fertilization rates, blastocyst formation, or implantation rates. Discussion: Here, the sperm source’s age did not affect the aneuploidy rate nor embryo implantation; however, with teratozoospermia, there was a weak association between the aneuploidy rate and age. Therefore, it would be prudent to perform PGT-A when advanced age and teratozoospermia are detected. |
| format | Article |
| id | doaj-art-d13f9e60e9b94f9bbc8a305b68bf9a03 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-d13f9e60e9b94f9bbc8a305b68bf9a032025-08-20T03:48:32ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-12-014861404141110.31083/j.ceog4806222S0390-6663(21)01642-0Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cyclesJeimy Pedraza0Hugo Sierra1Jacqueline Cordero2Esther López-Bayghen3Laboratorio de Fertilización in Vitro, Instituto de Infertilidad y Genética México SC, Ingenes, 05320 México City, MéxicoLaboratorio de Fertilización in Vitro, Instituto de Infertilidad y Genética México SC, Ingenes, 05320 México City, MéxicoLaboratorio de Fertilización in Vitro, Instituto de Infertilidad y Genética México SC, Ingenes, 05320 México City, MéxicoDepartamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), 07360 México City, MéxicoBackground: A wide variety of studies demonstrate the influence of the oocyte source’s age on the success of assisted reproduction treatments; however, the effect of paternal age has been studied to a lesser extent. Therefore, our goal was to assess the impact of male age and sperm quality on in vitro fertilization (IVF) outcomes. Methods: Three hundred ninety-four ova donation IVF cycles from Ingenes México were retrospectively analyzed. All ova donors (age range: 18–35 years) underwent a similar IVF stimulation protocol. The oocytes were aspirated and inseminated by intracytoplasmic sperm injection (ICSI) using either partner sperm (n = 332, age: 42.4 ± 7.4 years) or donor sperm (n = 62, age: 25.0 ± 3.3 years). Semen characteristics were evaluated by a seminogram. Biopsies were performed on Day 5 or Day 6, and Preimplantation Genetic Testing for Aneuploidies (PGT-A) was used to determine chromosome integrity with Next-Generation Sequencing. Results: A total of 1449 embryos were biopsied, 995 Day 5 and 454 Day 6. The aneuploidy rates for Day 5 and Day 6 embryos were not significantly different (22.2% and 22.7%, respectively). Independent of the sperm source, there was no observable trend between embryo aneuploidy rates and the sperm source’s age; however, when considering paternal sperm with teratozoospermia, a significant association was observed (rho = 0.165, p = 0.041). Sperm quality showed no effect on fertilization rates, blastocyst formation, or implantation rates. Discussion: Here, the sperm source’s age did not affect the aneuploidy rate nor embryo implantation; however, with teratozoospermia, there was a weak association between the aneuploidy rate and age. Therefore, it would be prudent to perform PGT-A when advanced age and teratozoospermia are detected.https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806222aneuploidyegg donorin vitro fertilizationpaternal agepreimplantation genetic screening |
| spellingShingle | Jeimy Pedraza Hugo Sierra Jacqueline Cordero Esther López-Bayghen Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles Clinical and Experimental Obstetrics & Gynecology aneuploidy egg donor in vitro fertilization paternal age preimplantation genetic screening |
| title | Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles |
| title_full | Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles |
| title_fullStr | Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles |
| title_full_unstemmed | Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles |
| title_short | Paternal advanced age and sperm quality are indicators for Preimplantation Genetic Testing in egg donation cycles |
| title_sort | paternal advanced age and sperm quality are indicators for preimplantation genetic testing in egg donation cycles |
| topic | aneuploidy egg donor in vitro fertilization paternal age preimplantation genetic screening |
| url | https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806222 |
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