Atopic dermatitis-alleviating effects of lactiplantibacillus plantarum LRCC5195 paraprobiotics through microbiome modulation and safety assessment via genomic characterization and in vitro analysis

Atopic dermatitis-alleviating effects of lactiplantibacillus plantarum LRCC5195 paraprobiotics through microbiome modulation and safety assessment via genomic characterization and in vitro analysis

Abstract The efficacy of paraprobiotics from Lactiplantibacillus plantarum LRCC5195 (LP5195-P) in alleviating atopic dermatitis (AD) through microbiome modulation and its safety were evaluated in AD-induced mice. Oral administration of LP5195-P to mice for 8 weeks after AD induction was used to inve...

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Main Authors: Ahyoung Lim, Jihye Baek, Minju Seo, Ki-young Kim, Seonghan Kim, Woongkwon Kwak, Jaeho Lee, Jungki Kwak, Won-Joo Yoon, Wonyong Kim, Seokmin Yoon
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Atopic dermatitis
Lactiplantibacillus plantarum
Paraprobiotics
Gut microbiome
Genome characterization
Safety
Online Access:https://doi.org/10.1038/s41598-025-16102-5
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https://doi.org/10.1038/s41598-025-16102-5

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