Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids
A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecul...
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| Format: | Article |
| Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2022-12-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/6325 |
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| author | Sergei N. Igidov Dmitriy V. Lipin Aleksey Yu. Turyshev Svetlana V. Chashchina Daria A. Shipilovskikh Ol’ga V. Zvereva Ksenia A. Mitusova Pavel S. Silaichev Nazim M. Igidov |
| author_facet | Sergei N. Igidov Dmitriy V. Lipin Aleksey Yu. Turyshev Svetlana V. Chashchina Daria A. Shipilovskikh Ol’ga V. Zvereva Ksenia A. Mitusova Pavel S. Silaichev Nazim M. Igidov |
| author_sort | Sergei N. Igidov |
| collection | DOAJ |
| description | A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity. |
| format | Article |
| id | doaj-art-d117235c69e44a6bb3cd14b35761ecef |
| institution | Kabale University |
| issn | 2411-1414 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-d117235c69e44a6bb3cd14b35761ecef2024-12-25T09:36:55ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142022-12-0110110.15826/chimtech.2023.10.1.024734Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic AcidsSergei N. Igidov0Dmitriy V. Lipin1Aleksey Yu. Turyshev2Svetlana V. Chashchina3Daria A. Shipilovskikh4Ol’ga V. Zvereva5Ksenia A. Mitusova6Pavel S. Silaichev7Nazim M. Igidov8Perm State Pharmaceutical Academy; Merck LLCPerm State National Research UniversityPerm State Pharmaceutical AcademyPerm State Pharmaceutical AcademyPerm National Research Polytechnic UniversityPerm State Pharmaceutical AcademyPeter the Great St. Petersburg Polytechnic UniversityPerm State National Research UniversityPerm State Pharmaceutical AcademyA method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.https://chimicatechnoacta.ru/article/view/6325dioxobutanoic acids2-hydrazono-4-oxobutanoic acids3-hydrazonofuran-2(3h)-onesanti-inflammatory activitydrugs |
| spellingShingle | Sergei N. Igidov Dmitriy V. Lipin Aleksey Yu. Turyshev Svetlana V. Chashchina Daria A. Shipilovskikh Ol’ga V. Zvereva Ksenia A. Mitusova Pavel S. Silaichev Nazim M. Igidov Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids Chimica Techno Acta dioxobutanoic acids 2-hydrazono-4-oxobutanoic acids 3-hydrazonofuran-2(3h)-ones anti-inflammatory activity drugs |
| title | Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids |
| title_full | Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids |
| title_fullStr | Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids |
| title_full_unstemmed | Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids |
| title_short | Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids |
| title_sort | synthesis intramolecular cyclization and anti inflammatory activity of substituted 2 2 furan 2 carbonyl hydrazono 4 oxobutanoic acids |
| topic | dioxobutanoic acids 2-hydrazono-4-oxobutanoic acids 3-hydrazonofuran-2(3h)-ones anti-inflammatory activity drugs |
| url | https://chimicatechnoacta.ru/article/view/6325 |
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