Leaderless foot-and-mouth disease virus serotype O did not cause clinical disease and failed to establish a persistent infection in cattle

Leaderless foot-and-mouth disease virus serotype O did not cause clinical disease and failed to establish a persistent infection in cattle

The foot-and-mouth disease virus (FMDV) Leader proteinase Lpro inhibits host mRNA translation and blocks the interferon response which promotes viral survival. Lpro is not required for viral replication in vitro but serotype A FMDV lacking Lpro has been shown to be attenuated in cattle and pigs. How...

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Bibliographic Details
Main Authors: Benedikt Litz, Julia Sehl-Ewert, Angele Breithaupt, Anja Landmesser, Florian Pfaff, Aurore Romey, Sandra Blaise-Boisseau, Martin Beer, Michael Eschbaumer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Foot-and-mouth disease virus
FMDV
persistence
carrier
leader proteinase
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2348526
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