Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal
Clinical trials (CT) have been the cornerstones in developing medicines, vaccines, and new interventions. Despite tremendous efforts, a CT cannot succeed without participants’ involvement. Various factors can affect people’s attitude and participation in a CT. Hence, this study was conducted to asse...
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2416760 |
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| author | Shipra Chaudhary Surendra Uranw Basant Rai Nisha Keshary Bhatta Gauri Shankar Shah Prakash Poudel Basudha Khanal Rosan Prasad Shah Kalawar Nikita Rai Jenisha Shrestha Merina Shrestha Shalu Parajuli Birendra Prasad Gupta Sridhar Vemula Katerina Rok Song Julia Lynch Tarun Saluja |
| author_facet | Shipra Chaudhary Surendra Uranw Basant Rai Nisha Keshary Bhatta Gauri Shankar Shah Prakash Poudel Basudha Khanal Rosan Prasad Shah Kalawar Nikita Rai Jenisha Shrestha Merina Shrestha Shalu Parajuli Birendra Prasad Gupta Sridhar Vemula Katerina Rok Song Julia Lynch Tarun Saluja |
| author_sort | Shipra Chaudhary |
| collection | DOAJ |
| description | Clinical trials (CT) have been the cornerstones in developing medicines, vaccines, and new interventions. Despite tremendous efforts, a CT cannot succeed without participants’ involvement. Various factors can affect people’s attitude and participation in a CT. Hence, this study was conducted to assess the knowledge and perception of a clinical trial among the participants of a CT at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. This was a population-based descriptive cross-sectional study conducted during 2021–2022. Participants involved in a phase III clinical trial were enrolled, and an in-depth interview was conducted using a semi-structured questionnaire. Demographic information, knowledge and perception about CT were assessed, and a descriptive analysis was done. Among 622 participants, the majority were males (321; 51.6%), literate (587; 94.37%), of indigenous ethnic groups (Janajatis 61.4%), and without previous experience of CT (504; 81.1%). The majority had adequate knowledge (566/622; 91%) and positive perception (595/622; 95.7%) of CT. Most participants (467; 75.1%) had participated in CT to get protection from the particular disease from the provided vaccine and (603; 96.9%) believed CT to benefit mankind. Further studies comparing pre- and post-participation knowledge and perception might be helpful for planning and better management of CTs in such settings. |
| format | Article |
| id | doaj-art-d0dca35a6f6e4b8e9610f636522d83e4 |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-d0dca35a6f6e4b8e9610f636522d83e42025-08-20T03:22:21ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2416760Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, NepalShipra Chaudhary0Surendra Uranw1Basant Rai2Nisha Keshary Bhatta3Gauri Shankar Shah4Prakash Poudel5Basudha Khanal6Rosan Prasad Shah Kalawar7Nikita Rai8Jenisha Shrestha9Merina Shrestha10Shalu Parajuli11Birendra Prasad Gupta12Sridhar Vemula13Katerina Rok Song14Julia Lynch15Tarun Saluja16Department of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Internal Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalDepartment of Orthopedics, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalOral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalOral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalOral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalOral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, NepalClinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of KoreaClinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of KoreaClinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of KoreaClinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of KoreaClinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of KoreaClinical trials (CT) have been the cornerstones in developing medicines, vaccines, and new interventions. Despite tremendous efforts, a CT cannot succeed without participants’ involvement. Various factors can affect people’s attitude and participation in a CT. Hence, this study was conducted to assess the knowledge and perception of a clinical trial among the participants of a CT at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. This was a population-based descriptive cross-sectional study conducted during 2021–2022. Participants involved in a phase III clinical trial were enrolled, and an in-depth interview was conducted using a semi-structured questionnaire. Demographic information, knowledge and perception about CT were assessed, and a descriptive analysis was done. Among 622 participants, the majority were males (321; 51.6%), literate (587; 94.37%), of indigenous ethnic groups (Janajatis 61.4%), and without previous experience of CT (504; 81.1%). The majority had adequate knowledge (566/622; 91%) and positive perception (595/622; 95.7%) of CT. Most participants (467; 75.1%) had participated in CT to get protection from the particular disease from the provided vaccine and (603; 96.9%) believed CT to benefit mankind. Further studies comparing pre- and post-participation knowledge and perception might be helpful for planning and better management of CTs in such settings.https://www.tandfonline.com/doi/10.1080/21645515.2024.2416760Clinical trialknowledgeperceptionparticipantsoral cholera vaccine |
| spellingShingle | Shipra Chaudhary Surendra Uranw Basant Rai Nisha Keshary Bhatta Gauri Shankar Shah Prakash Poudel Basudha Khanal Rosan Prasad Shah Kalawar Nikita Rai Jenisha Shrestha Merina Shrestha Shalu Parajuli Birendra Prasad Gupta Sridhar Vemula Katerina Rok Song Julia Lynch Tarun Saluja Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal Human Vaccines & Immunotherapeutics Clinical trial knowledge perception participants oral cholera vaccine |
| title | Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal |
| title_full | Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal |
| title_fullStr | Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal |
| title_full_unstemmed | Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal |
| title_short | Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal |
| title_sort | knowledge and perception of a clinical trial among the participants an experience from oral cholera vaccine study in koshi province nepal |
| topic | Clinical trial knowledge perception participants oral cholera vaccine |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2416760 |
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