OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice

OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice

Abstract Proinsulin translation and folding is crucial for glucose homeostasis. However, islet β-cell control of Proinsulin translation remains incompletely understood. Here, we identify OSGEP, an enzyme responsible for t6A37 modification of tRNANNU that tunes glucose metabolism in β-cells. Global O...

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Main Authors: Yujie Liu, Xuechun Yang, Jian Zhou, Haijun Yang, Ruimeng Yang, Peng Zhu, Rong Zhou, Tianyuan Wu, Yongchao Gao, Zhi Ye, Xi Li, Rong Liu, Wei Zhang, Honghao Zhou, Qing Li
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54905-8
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