Dysregulation of ubiquitination modification in renal cell carcinoma
Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1453191/full |
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| _version_ | 1846116350513119232 |
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| author | Hongjie You Hui Zhang Xiaofeng Jin Zejun Yan |
| author_facet | Hongjie You Hui Zhang Xiaofeng Jin Zejun Yan |
| author_sort | Hongjie You |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases. Additionally, we discuss research progress in RCC treatment by targeting key enzymes related to ubiquitination modifications. |
| format | Article |
| id | doaj-art-d0cc33e4fea540a5b983204a6adf9ec4 |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-d0cc33e4fea540a5b983204a6adf9ec42024-12-19T06:24:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-12-011510.3389/fgene.2024.14531911453191Dysregulation of ubiquitination modification in renal cell carcinomaHongjie YouHui ZhangXiaofeng JinZejun YanRenal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases. Additionally, we discuss research progress in RCC treatment by targeting key enzymes related to ubiquitination modifications.https://www.frontiersin.org/articles/10.3389/fgene.2024.1453191/fullE3 ubiquitin ligasesrenal cell carcinoma (RCC)ubiquitinationPROTACimmunotherapydeubiquitinase |
| spellingShingle | Hongjie You Hui Zhang Xiaofeng Jin Zejun Yan Dysregulation of ubiquitination modification in renal cell carcinoma Frontiers in Genetics E3 ubiquitin ligases renal cell carcinoma (RCC) ubiquitination PROTAC immunotherapy deubiquitinase |
| title | Dysregulation of ubiquitination modification in renal cell carcinoma |
| title_full | Dysregulation of ubiquitination modification in renal cell carcinoma |
| title_fullStr | Dysregulation of ubiquitination modification in renal cell carcinoma |
| title_full_unstemmed | Dysregulation of ubiquitination modification in renal cell carcinoma |
| title_short | Dysregulation of ubiquitination modification in renal cell carcinoma |
| title_sort | dysregulation of ubiquitination modification in renal cell carcinoma |
| topic | E3 ubiquitin ligases renal cell carcinoma (RCC) ubiquitination PROTAC immunotherapy deubiquitinase |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1453191/full |
| work_keys_str_mv | AT hongjieyou dysregulationofubiquitinationmodificationinrenalcellcarcinoma AT huizhang dysregulationofubiquitinationmodificationinrenalcellcarcinoma AT xiaofengjin dysregulationofubiquitinationmodificationinrenalcellcarcinoma AT zejunyan dysregulationofubiquitinationmodificationinrenalcellcarcinoma |