Pediatric neuro-oncology: Highlights of the last quarter-century
The last quarter century has heralded dramatic changes in the field of pediatric neuro-oncology, with the era defined by profound developments in the understanding of the biological underpinnings of childhood central nervous system (CNS) tumors and translational therapeutics. Although there have bee...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558624001398 |
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| author | Phoebe Power Joelle P Straehla Jason Fangusaro Pratiti Bandopadhayay Neevika Manoharan |
| author_facet | Phoebe Power Joelle P Straehla Jason Fangusaro Pratiti Bandopadhayay Neevika Manoharan |
| author_sort | Phoebe Power |
| collection | DOAJ |
| description | The last quarter century has heralded dramatic changes in the field of pediatric neuro-oncology, with the era defined by profound developments in the understanding of the biological underpinnings of childhood central nervous system (CNS) tumors and translational therapeutics. Although there have been momentous strides forward in biologic, diagnostic, therapeutic, and experimental domains, considerable challenges remain and CNS tumors remain the leading cause of pediatric cancer-related mortality. Here, we review the significant advances in the field of pediatric neuro-oncology over the last 25 years and highlight ongoing hurdles facing future progress. |
| format | Article |
| id | doaj-art-d0c9a89c9ecb4dd2abc4c37fc56da98c |
| institution | Kabale University |
| issn | 1476-5586 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj-art-d0c9a89c9ecb4dd2abc4c37fc56da98c2024-12-17T04:59:05ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862025-01-0159101098Pediatric neuro-oncology: Highlights of the last quarter-centuryPhoebe Power0Joelle P Straehla1Jason Fangusaro2Pratiti Bandopadhayay3Neevika Manoharan4Department of Pediatric Oncology, Dana-Farber/ Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Cambridge, MA, USABen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USAChildren's Healthcare of Atlanta, Emory University, Atlanta, GA, USA; Aflac Cancer Center, Atlanta, GA, USADepartment of Pediatric Oncology, Dana-Farber/ Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USAKids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia; Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia; Correspondence author at: Kids Cancer Center, High St, Randwick NSW 2031 Australia.The last quarter century has heralded dramatic changes in the field of pediatric neuro-oncology, with the era defined by profound developments in the understanding of the biological underpinnings of childhood central nervous system (CNS) tumors and translational therapeutics. Although there have been momentous strides forward in biologic, diagnostic, therapeutic, and experimental domains, considerable challenges remain and CNS tumors remain the leading cause of pediatric cancer-related mortality. Here, we review the significant advances in the field of pediatric neuro-oncology over the last 25 years and highlight ongoing hurdles facing future progress.http://www.sciencedirect.com/science/article/pii/S1476558624001398Pediatric neuro-oncologypLGGDMGMedulloblastomaTargeted therapyImmunotherapy |
| spellingShingle | Phoebe Power Joelle P Straehla Jason Fangusaro Pratiti Bandopadhayay Neevika Manoharan Pediatric neuro-oncology: Highlights of the last quarter-century Neoplasia: An International Journal for Oncology Research Pediatric neuro-oncology pLGG DMG Medulloblastoma Targeted therapy Immunotherapy |
| title | Pediatric neuro-oncology: Highlights of the last quarter-century |
| title_full | Pediatric neuro-oncology: Highlights of the last quarter-century |
| title_fullStr | Pediatric neuro-oncology: Highlights of the last quarter-century |
| title_full_unstemmed | Pediatric neuro-oncology: Highlights of the last quarter-century |
| title_short | Pediatric neuro-oncology: Highlights of the last quarter-century |
| title_sort | pediatric neuro oncology highlights of the last quarter century |
| topic | Pediatric neuro-oncology pLGG DMG Medulloblastoma Targeted therapy Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S1476558624001398 |
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