Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event
Objective To determine the effects of yoga practice on subclinical cardiovascular measures, risk factors and neuro-endocrine pathways in patients undergoing cardiac rehabilitation (CR) following acute coronary events.Design 3-month, two-arm (yoga +usual care vs usual care alone) parallel randomised...
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BMJ Publishing Group
2019-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/11/e030119.full |
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| author | Naveed Sattar Ian Roberts Sanjay Kinra Paul Welsh Therese Tillin A Hughes Kaushik Chattopadhyay Shah Ebrahim Claire Tuson Barbara Sowa Nishi Chaturvedi |
| author_facet | Naveed Sattar Ian Roberts Sanjay Kinra Paul Welsh Therese Tillin A Hughes Kaushik Chattopadhyay Shah Ebrahim Claire Tuson Barbara Sowa Nishi Chaturvedi |
| author_sort | Naveed Sattar |
| collection | DOAJ |
| description | Objective To determine the effects of yoga practice on subclinical cardiovascular measures, risk factors and neuro-endocrine pathways in patients undergoing cardiac rehabilitation (CR) following acute coronary events.Design 3-month, two-arm (yoga +usual care vs usual care alone) parallel randomised mechanistic study.Setting One general hospital and two primary care CR centres in London. Assessments were conducted at Imperial College London.Participants 80 participants, aged 35–80 years (68% men, 60% South Asian) referred to CR programmes 2012–2014.Intervention A certified yoga teacher conducted yoga classes which included exercises in stretching, breathing, healing imagery and deep relaxation. It was pre-specified that at least 18 yoga classes were attended for inclusion in analysis. Participants and partners in both groups were invited to attend weekly a 6- to 12-week local standard UK National Health Service CR programme.Main outcome measures (i) Estimated left ventricular filling pressure (E/e′), (ii) distance walked, fatigue and breathlessness in a 6 min walk test, (iii) blood pressure, heart rate and estimated peak VO2 following a 3 min step-test. Effects on the hypothalamus–pituitary–adrenal axis, autonomic function, body fat, blood lipids and glucose, stress and general health were also explored.Results 25 participants in the yoga + usual care group and 35 participants in the usual care group completed the study. Following the 3-month intervention period, E/e′ was not improved by yoga (E/e′: between-group difference: yoga minus usual care:−0.40 (−1.38, 0.58). Exercise testing and secondary outcomes also showed no benefits of yoga.Conclusions In this small UK-based randomised mechanistic study, with 60 completing participants (of whom 25 were in the yoga + usual care group), we found no discernible improvement associated with the addition of a structured 3-month yoga intervention to usual CR care in key cardiovascular and neuroendocrine measures shown to be responsive to yoga in previous mechanistic studies.Trial registration number NCT01597960; Pre-results. |
| format | Article |
| id | doaj-art-d0c5a98afc1c45fab675a41f22d8c9dd |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d0c5a98afc1c45fab675a41f22d8c9dd2024-11-30T18:05:13ZengBMJ Publishing GroupBMJ Open2044-60552019-11-0191110.1136/bmjopen-2019-030119Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary eventNaveed Sattar0Ian Roberts1Sanjay Kinra2Paul Welsh3Therese Tillin4A Hughes5Kaushik Chattopadhyay6Shah Ebrahim7Claire Tuson8Barbara Sowa9Nishi Chaturvedi101 British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC), Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK2 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK7 Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UKBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UKMRC Unit for Lifelong Health and Ageing, London, UK1MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK4 Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UKprofessor of public health2 York Hospitals NHS Trust, York, UK3 West London Mental Health NHS Trust, Southall, UK2 MRC Unit for Lifelong Health and Aging, UCL Institute of Cardiovascular Science, University College London, London, UKObjective To determine the effects of yoga practice on subclinical cardiovascular measures, risk factors and neuro-endocrine pathways in patients undergoing cardiac rehabilitation (CR) following acute coronary events.Design 3-month, two-arm (yoga +usual care vs usual care alone) parallel randomised mechanistic study.Setting One general hospital and two primary care CR centres in London. Assessments were conducted at Imperial College London.Participants 80 participants, aged 35–80 years (68% men, 60% South Asian) referred to CR programmes 2012–2014.Intervention A certified yoga teacher conducted yoga classes which included exercises in stretching, breathing, healing imagery and deep relaxation. It was pre-specified that at least 18 yoga classes were attended for inclusion in analysis. Participants and partners in both groups were invited to attend weekly a 6- to 12-week local standard UK National Health Service CR programme.Main outcome measures (i) Estimated left ventricular filling pressure (E/e′), (ii) distance walked, fatigue and breathlessness in a 6 min walk test, (iii) blood pressure, heart rate and estimated peak VO2 following a 3 min step-test. Effects on the hypothalamus–pituitary–adrenal axis, autonomic function, body fat, blood lipids and glucose, stress and general health were also explored.Results 25 participants in the yoga + usual care group and 35 participants in the usual care group completed the study. Following the 3-month intervention period, E/e′ was not improved by yoga (E/e′: between-group difference: yoga minus usual care:−0.40 (−1.38, 0.58). Exercise testing and secondary outcomes also showed no benefits of yoga.Conclusions In this small UK-based randomised mechanistic study, with 60 completing participants (of whom 25 were in the yoga + usual care group), we found no discernible improvement associated with the addition of a structured 3-month yoga intervention to usual CR care in key cardiovascular and neuroendocrine measures shown to be responsive to yoga in previous mechanistic studies.Trial registration number NCT01597960; Pre-results.https://bmjopen.bmj.com/content/9/11/e030119.full |
| spellingShingle | Naveed Sattar Ian Roberts Sanjay Kinra Paul Welsh Therese Tillin A Hughes Kaushik Chattopadhyay Shah Ebrahim Claire Tuson Barbara Sowa Nishi Chaturvedi Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event BMJ Open |
| title | Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event |
| title_full | Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event |
| title_fullStr | Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event |
| title_full_unstemmed | Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event |
| title_short | Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event |
| title_sort | yoga and cardiovascular health trial yacht a uk based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event |
| url | https://bmjopen.bmj.com/content/9/11/e030119.full |
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