Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research
Alzheimer’s Disease (AD) is a neurodegenerative disorder marked by cognitive decline, for which effective treatments remain elusive due to complex pathogenesis. Recent advances in neuroimaging, gene therapy, and gut microbiota research offer new insights and potential intervention strategies. Neuroi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1485657/full |
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| author | Haitao Wang Haitao Wang Chen Shi Ling Jiang Xiaozhu Liu Rui Tang Mingxi Tang Mingxi Tang |
| author_facet | Haitao Wang Haitao Wang Chen Shi Ling Jiang Xiaozhu Liu Rui Tang Mingxi Tang Mingxi Tang |
| author_sort | Haitao Wang |
| collection | DOAJ |
| description | Alzheimer’s Disease (AD) is a neurodegenerative disorder marked by cognitive decline, for which effective treatments remain elusive due to complex pathogenesis. Recent advances in neuroimaging, gene therapy, and gut microbiota research offer new insights and potential intervention strategies. Neuroimaging enables early detection and staging of AD through visualization of biomarkers, aiding diagnosis and tracking of disease progression. Gene therapy presents a promising approach for modifying AD-related genetic expressions, targeting amyloid and tau pathology, and potentially repairing neuronal damage. Furthermore, emerging evidence suggests that the gut microbiota influences AD pathology through the gut-brain axis, impacting inflammation, immune response, and amyloid metabolism. However, each of these technologies faces significant challenges, including concerns about safety, efficacy, and ethical considerations. This article reviews the applications, advantages, and limitations of neuroimaging, gene therapy, and gut microbiota research in AD, with a particular focus on their combined potential for early diagnosis, mechanistic insights, and therapeutic interventions. We propose an integrated approach that leverages these tools to provide a multi-dimensional framework for advancing AD diagnosis, treatment, and prevention. |
| format | Article |
| id | doaj-art-d0a8e85b8d344e098e04fd09a44944af |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-d0a8e85b8d344e098e04fd09a44944af2024-12-03T06:30:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-12-011610.3389/fnagi.2024.14856571485657Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease researchHaitao Wang0Haitao Wang1Chen Shi2Ling Jiang3Xiaozhu Liu4Rui Tang5Mingxi Tang6Mingxi Tang7School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaThe School of Clinical Medical Sciences, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Gynaecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Anorectal, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaEmergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaSchool of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pathology, Yaan People’s Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan, Sichuan, ChinaAlzheimer’s Disease (AD) is a neurodegenerative disorder marked by cognitive decline, for which effective treatments remain elusive due to complex pathogenesis. Recent advances in neuroimaging, gene therapy, and gut microbiota research offer new insights and potential intervention strategies. Neuroimaging enables early detection and staging of AD through visualization of biomarkers, aiding diagnosis and tracking of disease progression. Gene therapy presents a promising approach for modifying AD-related genetic expressions, targeting amyloid and tau pathology, and potentially repairing neuronal damage. Furthermore, emerging evidence suggests that the gut microbiota influences AD pathology through the gut-brain axis, impacting inflammation, immune response, and amyloid metabolism. However, each of these technologies faces significant challenges, including concerns about safety, efficacy, and ethical considerations. This article reviews the applications, advantages, and limitations of neuroimaging, gene therapy, and gut microbiota research in AD, with a particular focus on their combined potential for early diagnosis, mechanistic insights, and therapeutic interventions. We propose an integrated approach that leverages these tools to provide a multi-dimensional framework for advancing AD diagnosis, treatment, and prevention.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1485657/fullAlzheimer’s Diseaseneuroimaging techniquesgene therapygut microbiotafrontier advancesinterdisciplinary research |
| spellingShingle | Haitao Wang Haitao Wang Chen Shi Ling Jiang Xiaozhu Liu Rui Tang Mingxi Tang Mingxi Tang Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research Frontiers in Aging Neuroscience Alzheimer’s Disease neuroimaging techniques gene therapy gut microbiota frontier advances interdisciplinary research |
| title | Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research |
| title_full | Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research |
| title_fullStr | Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research |
| title_full_unstemmed | Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research |
| title_short | Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research |
| title_sort | neuroimaging techniques gene therapy and gut microbiota frontier advances and integrated applications in alzheimer s disease research |
| topic | Alzheimer’s Disease neuroimaging techniques gene therapy gut microbiota frontier advances interdisciplinary research |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1485657/full |
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