A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma

A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma

Abstract Background Childhood asthma presents a multifaceted immune-driven pathology shaped by genetic, epigenetic, and immune regulatory interactions. Despite extensive genome-wide analyses pinpointing multiple susceptibility loci, the precise functional contributors to asthma pathogenesis remain e...

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Bibliographic Details
Main Authors: Yuan Zhang, Xiaochen Du, Yujuan Yang, Yaqiong Ren, Lijun Zhou, Jun Hua, Hongying Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Clinical Epigenetics
Subjects:
Childhood asthma
STX4
Multi-omics
Mendelian randomization
Colocalization
pQTL
Online Access:https://doi.org/10.1186/s13148-025-01908-x
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