Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties
Acanthospermum hispidum DC. is a plant with extensive traditional use in folk medicine for treatment of various infections in Sudan including jaundice, stomach discomfort, constipation, and viral infections. This research was carried out to explore the biological and chemical properties of the crude...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2024/8733990 |
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| author | Ehssan H. Moglad Alshaimaa A. Alnoor Nagla M. Eltayeb Eshtiyag A. Abdalkareem Amna Ali Magbool E. Oraiby Shahnaz Sultana Asaad Khalid Ashraf N. Abdalla |
| author_facet | Ehssan H. Moglad Alshaimaa A. Alnoor Nagla M. Eltayeb Eshtiyag A. Abdalkareem Amna Ali Magbool E. Oraiby Shahnaz Sultana Asaad Khalid Ashraf N. Abdalla |
| author_sort | Ehssan H. Moglad |
| collection | DOAJ |
| description | Acanthospermum hispidum DC. is a plant with extensive traditional use in folk medicine for treatment of various infections in Sudan including jaundice, stomach discomfort, constipation, and viral infections. This research was carried out to explore the biological and chemical properties of the crude extract of A. hispidum. Ethanol crude extract was prepared from the aerial parts of the plant and investigated for antibacterial action against standard monoderm and diderm bacteria using the cup plate method. Free radical scavenging was investigated out by using the DPPH method. Cytotoxicity assay was performed against human breast cancer cell line MCF7 using the MTT assay. Bioactive compounds were identified using GC-MS. The ethanolic extract of A. hispidum revealed antibacterial activity against all the tested bacteria. Also, the extract exhibited potent antioxidant activity at 0.5 mg/ml using DPPH (83% ± 00.09). The cytotoxicity against MCF7 revealed potent growth inhibition activity (IC50 75.8 µg/ml). GC-MS analysis revealed the presence of ethyl α-d-glucopyranoside, hexadecanoic acid, stigmasterol, β-sitosterol, undecanoic acid, phytol, alloaromadendrene oxide, 3-cyclopentylpropionic acid, 2-dimethylaminoethyl ester, and longifolenaldehyde in aerial parts of A. hispidum, all of which support antibacterial, antioxidant, and cytotoxic properties. |
| format | Article |
| id | doaj-art-d08ed4836c0546efac426b858e940e9a |
| institution | Kabale University |
| issn | 2314-4939 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-d08ed4836c0546efac426b858e940e9a2025-01-03T01:44:18ZengWileyJournal of Spectroscopy2314-49392024-01-01202410.1155/2024/8733990Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer PropertiesEhssan H. Moglad0Alshaimaa A. Alnoor1Nagla M. Eltayeb2Eshtiyag A. Abdalkareem3Amna Ali4Magbool E. Oraiby5Shahnaz Sultana6Asaad Khalid7Ashraf N. Abdalla8Department of PharmaceuticsDepartment of ChemistryDepartment of Immunology and BiotechnologyDepartment of Immunology and BiotechnologyMedicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI)Poison Control and Medical Forensic Chemistry CenterDepartment of Pharmaceutical Chemistry and PharmacognosyMedicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI)Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI)Acanthospermum hispidum DC. is a plant with extensive traditional use in folk medicine for treatment of various infections in Sudan including jaundice, stomach discomfort, constipation, and viral infections. This research was carried out to explore the biological and chemical properties of the crude extract of A. hispidum. Ethanol crude extract was prepared from the aerial parts of the plant and investigated for antibacterial action against standard monoderm and diderm bacteria using the cup plate method. Free radical scavenging was investigated out by using the DPPH method. Cytotoxicity assay was performed against human breast cancer cell line MCF7 using the MTT assay. Bioactive compounds were identified using GC-MS. The ethanolic extract of A. hispidum revealed antibacterial activity against all the tested bacteria. Also, the extract exhibited potent antioxidant activity at 0.5 mg/ml using DPPH (83% ± 00.09). The cytotoxicity against MCF7 revealed potent growth inhibition activity (IC50 75.8 µg/ml). GC-MS analysis revealed the presence of ethyl α-d-glucopyranoside, hexadecanoic acid, stigmasterol, β-sitosterol, undecanoic acid, phytol, alloaromadendrene oxide, 3-cyclopentylpropionic acid, 2-dimethylaminoethyl ester, and longifolenaldehyde in aerial parts of A. hispidum, all of which support antibacterial, antioxidant, and cytotoxic properties.http://dx.doi.org/10.1155/2024/8733990 |
| spellingShingle | Ehssan H. Moglad Alshaimaa A. Alnoor Nagla M. Eltayeb Eshtiyag A. Abdalkareem Amna Ali Magbool E. Oraiby Shahnaz Sultana Asaad Khalid Ashraf N. Abdalla Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties Journal of Spectroscopy |
| title | Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties |
| title_full | Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties |
| title_fullStr | Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties |
| title_full_unstemmed | Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties |
| title_short | Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties |
| title_sort | therapeutic potential of acanthospermum hispidum a comprehensive analysis of its antimicrobial antioxidant and anticancer properties |
| url | http://dx.doi.org/10.1155/2024/8733990 |
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