Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention
Background: Elevated lipoprotein(a) (Lp[a]) is a risk factor for first atherosclerotic thrombosis events, but the role of elevated Lp(a) in secondary prevention is controversial. This study aimed to retrospectively investigate the influence of elevated Lp(a) levels on the prognosis of patients with...
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The Texas Heart Institute
2024-12-01
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| Series: | Texas Heart Institute Journal |
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| Online Access: | https://thij.staging.kglmeridian.com/downloadpdf/view/journals/thij/51/2/article-e238372.pdf |
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| author | Azhi ShaMa, MM Chunlan Ma, BS Yingying Huang, BS Jingyue Hu, BS Chunmei Xu, BS Zhuxin Li, BS Jing Wang, MD, PhD Chunyu Zeng, MD, PhD |
| author_facet | Azhi ShaMa, MM Chunlan Ma, BS Yingying Huang, BS Jingyue Hu, BS Chunmei Xu, BS Zhuxin Li, BS Jing Wang, MD, PhD Chunyu Zeng, MD, PhD |
| author_sort | Azhi ShaMa, MM |
| collection | DOAJ |
| description | Background:
Elevated lipoprotein(a) (Lp[a]) is a risk factor for first atherosclerotic thrombosis events, but the role of elevated Lp(a) in secondary prevention is controversial. This study aimed to retrospectively investigate the influence of elevated Lp(a) levels on the prognosis of patients with coronary artery disease.
Methods:
The team collected and compared clinical information of patients hospitalized during percutaneous coronary intervention (PCI). This study used a multivariate logistic regression model to evaluate the relationships between Lp(a) levels, cardiovascular risk factors, and the prognosis of coronary artery disease in patients undergoing PCI.
Results:
There were no statistically significant differences between patients grouped according to Lp(a) level in terms of sex; age; body mass index and obesity; hyperuricemia; smoking; cardiac insufficiency; acute myocardial infarction; multivessel lesion; in-stent restenosis; secondary PCI; apolipoprotein AI level; incidence of high total cholesterol or high low-density lipoprotein cholesterol; or family history of hypertension, diabetes, or coronary artery disease. The average Lp(a) concentration did not statistically significantly decrease after 1 year of statin treatment after PCI. One year after patients began statins, there were no significant differences between Lp(a) groups in the incidence of high triglycerides (P = .13), high total cholesterol (P = .52), or high low-density lipoprotein cholesterol (P = .051). Multivariate logistic regression analysis indicated that diabetes (P = .02) was associated with in-stent restenosis, whereas diabetes (P = .02) and multivessel lesions (P < .001) were associated with secondary PCI in patients who underwent coronary angiography 1 year after PCI. Compared with normal Lp(a) levels, high Lp(a) levels did not significantly increase the incidence of in-stent restenosis or secondary PCI in patients who underwent coronary angiography 1 year after PCI.
Conclusion:
Sustained high concentrations of Lp(a) did not significantly increase the incidence of in-stent restenosis or secondary PCI in patients who underwent coronary angiography 1 year after PCI. |
| format | Article |
| id | doaj-art-d086aa81f9f14cf1841c593ad0c5e38b |
| institution | Kabale University |
| issn | 1526-6702 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Texas Heart Institute |
| record_format | Article |
| series | Texas Heart Institute Journal |
| spelling | doaj-art-d086aa81f9f14cf1841c593ad0c5e38b2024-12-17T08:03:44ZengThe Texas Heart InstituteTexas Heart Institute Journal1526-67022024-12-015121810.14503/THIJ-23-8372i1526-6702-51-2-e238372Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary InterventionAzhi ShaMa, MM0Chunlan Ma, BS1Yingying Huang, BS2Jingyue Hu, BS3Chunmei Xu, BS4Zhuxin Li, BS5Jing Wang, MD, PhD6Chunyu Zeng, MD, PhD71 Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of China1 Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of China1 Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of China2 Department of Neurology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of China1 Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of China1 Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of China3 Department of Cardiology, The First Affiliated Hospital of Qunming Medical University, Qunming, Yunnan Province, People's Republic of China1 Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, People's Republic of ChinaBackground: Elevated lipoprotein(a) (Lp[a]) is a risk factor for first atherosclerotic thrombosis events, but the role of elevated Lp(a) in secondary prevention is controversial. This study aimed to retrospectively investigate the influence of elevated Lp(a) levels on the prognosis of patients with coronary artery disease. Methods: The team collected and compared clinical information of patients hospitalized during percutaneous coronary intervention (PCI). This study used a multivariate logistic regression model to evaluate the relationships between Lp(a) levels, cardiovascular risk factors, and the prognosis of coronary artery disease in patients undergoing PCI. Results: There were no statistically significant differences between patients grouped according to Lp(a) level in terms of sex; age; body mass index and obesity; hyperuricemia; smoking; cardiac insufficiency; acute myocardial infarction; multivessel lesion; in-stent restenosis; secondary PCI; apolipoprotein AI level; incidence of high total cholesterol or high low-density lipoprotein cholesterol; or family history of hypertension, diabetes, or coronary artery disease. The average Lp(a) concentration did not statistically significantly decrease after 1 year of statin treatment after PCI. One year after patients began statins, there were no significant differences between Lp(a) groups in the incidence of high triglycerides (P = .13), high total cholesterol (P = .52), or high low-density lipoprotein cholesterol (P = .051). Multivariate logistic regression analysis indicated that diabetes (P = .02) was associated with in-stent restenosis, whereas diabetes (P = .02) and multivessel lesions (P < .001) were associated with secondary PCI in patients who underwent coronary angiography 1 year after PCI. Compared with normal Lp(a) levels, high Lp(a) levels did not significantly increase the incidence of in-stent restenosis or secondary PCI in patients who underwent coronary angiography 1 year after PCI. Conclusion: Sustained high concentrations of Lp(a) did not significantly increase the incidence of in-stent restenosis or secondary PCI in patients who underwent coronary angiography 1 year after PCI.https://thij.staging.kglmeridian.com/downloadpdf/view/journals/thij/51/2/article-e238372.pdfcoronary artery diseasecoronary restenosislipoprotein(a)percutaneous coronary intervention |
| spellingShingle | Azhi ShaMa, MM Chunlan Ma, BS Yingying Huang, BS Jingyue Hu, BS Chunmei Xu, BS Zhuxin Li, BS Jing Wang, MD, PhD Chunyu Zeng, MD, PhD Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention Texas Heart Institute Journal coronary artery disease coronary restenosis lipoprotein(a) percutaneous coronary intervention |
| title | Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention |
| title_full | Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention |
| title_fullStr | Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention |
| title_full_unstemmed | Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention |
| title_short | Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention |
| title_sort | correlation between lipoprotein a and prognosis for coronary artery disease in patients undergoing percutaneous coronary intervention |
| topic | coronary artery disease coronary restenosis lipoprotein(a) percutaneous coronary intervention |
| url | https://thij.staging.kglmeridian.com/downloadpdf/view/journals/thij/51/2/article-e238372.pdf |
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