Skin microbiota: pathogenic roles and implications in atopic dermatitis
Atopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function and imbalanced immunity. Recent advances have revealed that dysbiosis of skin microbiota plays important roles in the pathogenesis and development of AD. Meanwhile, endogenous and external f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1518811/full |
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| author | Cong Huang Cong Huang Fan Zhuo Fan Zhuo Yang Guo Yang Guo Yang Guo Siyu Wang Siyu Wang Siyu Wang Siyu Wang Kaoyuan Zhang Kaoyuan Zhang Xiahong Li Xiahong Li Wenkui Dai Xia Dou Xia Dou Bo Yu Bo Yu |
| author_facet | Cong Huang Cong Huang Fan Zhuo Fan Zhuo Yang Guo Yang Guo Yang Guo Siyu Wang Siyu Wang Siyu Wang Siyu Wang Kaoyuan Zhang Kaoyuan Zhang Xiahong Li Xiahong Li Wenkui Dai Xia Dou Xia Dou Bo Yu Bo Yu |
| author_sort | Cong Huang |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function and imbalanced immunity. Recent advances have revealed that dysbiosis of skin microbiota plays important roles in the pathogenesis and development of AD. Meanwhile, endogenous and external factors contribute to the dysbiosis of skin microbiota in AD. Additionally, various treatments, including topical treatments, phototherapy, and systemic biologics, have demonstrated positive impacts on the clinical outcomes, alongside with the modulations of cutaneous microbiota in AD patients. Importantly, therapeutics or products regulating skin microbiota homeostasis have demonstrated potential for AD treatment in early clinical studies. In this review, we underline changes of the skin microbiota correlated with AD. Meanwhile, we provide an overview of the skin microbiota regarding its roles in the pathogenesis and development of AD. Finally, we summarize therapeutic strategies restoring the skin microbial homeostasis in AD management. |
| format | Article |
| id | doaj-art-d083ae3eee3947eea854faa5491137b7 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-d083ae3eee3947eea854faa5491137b72025-01-14T06:10:42ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.15188111518811Skin microbiota: pathogenic roles and implications in atopic dermatitisCong Huang0Cong Huang1Fan Zhuo2Fan Zhuo3Yang Guo4Yang Guo5Yang Guo6Siyu Wang7Siyu Wang8Siyu Wang9Siyu Wang10Kaoyuan Zhang11Kaoyuan Zhang12Xiahong Li13Xiahong Li14Wenkui Dai15Xia Dou16Xia Dou17Bo Yu18Bo Yu19Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Epidemiology and Statistics, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaDepartment of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen, ChinaAtopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function and imbalanced immunity. Recent advances have revealed that dysbiosis of skin microbiota plays important roles in the pathogenesis and development of AD. Meanwhile, endogenous and external factors contribute to the dysbiosis of skin microbiota in AD. Additionally, various treatments, including topical treatments, phototherapy, and systemic biologics, have demonstrated positive impacts on the clinical outcomes, alongside with the modulations of cutaneous microbiota in AD patients. Importantly, therapeutics or products regulating skin microbiota homeostasis have demonstrated potential for AD treatment in early clinical studies. In this review, we underline changes of the skin microbiota correlated with AD. Meanwhile, we provide an overview of the skin microbiota regarding its roles in the pathogenesis and development of AD. Finally, we summarize therapeutic strategies restoring the skin microbial homeostasis in AD management.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1518811/fullatopic dermatitisskin microbiotaStaphylococcus aureuspathogenesismicrobiota-based therapy |
| spellingShingle | Cong Huang Cong Huang Fan Zhuo Fan Zhuo Yang Guo Yang Guo Yang Guo Siyu Wang Siyu Wang Siyu Wang Siyu Wang Kaoyuan Zhang Kaoyuan Zhang Xiahong Li Xiahong Li Wenkui Dai Xia Dou Xia Dou Bo Yu Bo Yu Skin microbiota: pathogenic roles and implications in atopic dermatitis Frontiers in Cellular and Infection Microbiology atopic dermatitis skin microbiota Staphylococcus aureus pathogenesis microbiota-based therapy |
| title | Skin microbiota: pathogenic roles and implications in atopic dermatitis |
| title_full | Skin microbiota: pathogenic roles and implications in atopic dermatitis |
| title_fullStr | Skin microbiota: pathogenic roles and implications in atopic dermatitis |
| title_full_unstemmed | Skin microbiota: pathogenic roles and implications in atopic dermatitis |
| title_short | Skin microbiota: pathogenic roles and implications in atopic dermatitis |
| title_sort | skin microbiota pathogenic roles and implications in atopic dermatitis |
| topic | atopic dermatitis skin microbiota Staphylococcus aureus pathogenesis microbiota-based therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1518811/full |
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