Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives

Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives

Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl2-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by their reaction with nucleophiles are reported....

Full description

Saved in:
Bibliographic Details
Main Authors: Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov
Format: Article
Language:English
Published: Beilstein-Institut 2024-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
azirine-2,2-dicarboxamides
azirine-2,2-dicarboxylic acids
isomerization
isoxazoles
Online Access:https://doi.org/10.3762/bjoc.20.264
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl2-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by their reaction with nucleophiles are reported. Two approaches to the preparation of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides have been developed.
ISSN:1860-5397

Similar Items