Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications

Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications

BackgroundDiabetes remains a leading cause of morbidity and mortality due to various complications induced by hyperglycemia. Inhibiting Aldose Reductase (AR), an enzyme that converts glucose to sorbitol, has been studied to prevent long-term diabetic consequences. Unfortunately, drugs targeting AR h...

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Bibliographic Details
Main Authors: Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Bioinformatics
Subjects:
diabetes mellitus
aldose reductase
molecular docking
pharmacokinetics
molecular dynamics simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1499255/full
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