N,N-Diethylacetamide and N,N-Dipropylacetamide inhibit the NF-kB pathway in in vitro, ex vivo and in vivo models of inflammation-induced preterm birth

N,N-Diethylacetamide and N,N-Dipropylacetamide inhibit the NF-kB pathway in in vitro, ex vivo and in vivo models of inflammation-induced preterm birth

Abstract Preterm birth (PTB) occurs in 10% of births worldwide and remains the leading cause of neonatal morbidity and mortality. Previously, we reported that N, N-dimethylacetamide (DMA) and N, N-dimethylformamide (DMF) prevent inflammation-induced PTB in a murine model and inhibit the NF-κB inflam...

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Bibliographic Details
Main Authors: Samir Gorasiya, Juliet Mushi, Sabesan Yoganathan, Leonard Barasa, Ryan Pekson, Charles R. Ashby, Sandra E. Reznik
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
N,N-diethylacetamide
Inflammation
NF-κB
IκB-α
Macrophage
Online Access:https://doi.org/10.1038/s41598-025-16076-4
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