Cyclophilin A: promising target in cancer therapy
Cyclophilin A (CypA), a member of the immunophilin family, stands out as the most prevalent among the cyclophilins found in humans. Beyond serving as the intracellular receptor for the immunosuppressive drug cyclosporine A (CsA), CypA exerts critical functions within the cell via its peptidyl-prolyl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2425127 |
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| _version_ | 1846126016963018752 |
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| author | Shujuan Jin Mengjiao Zhang Xiaoting Qiao |
| author_facet | Shujuan Jin Mengjiao Zhang Xiaoting Qiao |
| author_sort | Shujuan Jin |
| collection | DOAJ |
| description | Cyclophilin A (CypA), a member of the immunophilin family, stands out as the most prevalent among the cyclophilins found in humans. Beyond serving as the intracellular receptor for the immunosuppressive drug cyclosporine A (CsA), CypA exerts critical functions within the cell via its peptidyl-prolyl cis-trans isomerase (PPIase) activity, which is crucial for processes, such as protein folding, trafficking, assembly, modulation of immune responses, and cell signaling. Increasing evidence indicates that CypA is up-regulated in a variety of human cancers and it may be a novel potential therapeutic target for cancer treatment. Therefore, gaining a thorough understanding of CypA’s contribution to cancer could yield fresh perspectives and inform the development of innovative therapeutic approaches. This review delves into the multifaceted roles of CypA in cancer biology and explores the therapeutic potential of targeting CypA. |
| format | Article |
| id | doaj-art-cfceb34f18704a14874bd39c49b4fc7f |
| institution | Kabale University |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-cfceb34f18704a14874bd39c49b4fc7f2024-12-13T06:53:24ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2425127Cyclophilin A: promising target in cancer therapyShujuan Jin0Mengjiao Zhang1Xiaoting Qiao2Shenzhen Institute for Technology Innovation, National Institute of Metrology, Shenzhen, Guangdong, ChinaChenxi Women’s and Children’s Hospital, Huaihua, Hunan, ChinaShenzhen Institute for Technology Innovation, National Institute of Metrology, Shenzhen, Guangdong, ChinaCyclophilin A (CypA), a member of the immunophilin family, stands out as the most prevalent among the cyclophilins found in humans. Beyond serving as the intracellular receptor for the immunosuppressive drug cyclosporine A (CsA), CypA exerts critical functions within the cell via its peptidyl-prolyl cis-trans isomerase (PPIase) activity, which is crucial for processes, such as protein folding, trafficking, assembly, modulation of immune responses, and cell signaling. Increasing evidence indicates that CypA is up-regulated in a variety of human cancers and it may be a novel potential therapeutic target for cancer treatment. Therefore, gaining a thorough understanding of CypA’s contribution to cancer could yield fresh perspectives and inform the development of innovative therapeutic approaches. This review delves into the multifaceted roles of CypA in cancer biology and explores the therapeutic potential of targeting CypA.https://www.tandfonline.com/doi/10.1080/15384047.2024.2425127Cyclophilin aPPIaseCD147cell proliferationcell invasiondrug resistance |
| spellingShingle | Shujuan Jin Mengjiao Zhang Xiaoting Qiao Cyclophilin A: promising target in cancer therapy Cancer Biology & Therapy Cyclophilin a PPIase CD147 cell proliferation cell invasion drug resistance |
| title | Cyclophilin A: promising target in cancer therapy |
| title_full | Cyclophilin A: promising target in cancer therapy |
| title_fullStr | Cyclophilin A: promising target in cancer therapy |
| title_full_unstemmed | Cyclophilin A: promising target in cancer therapy |
| title_short | Cyclophilin A: promising target in cancer therapy |
| title_sort | cyclophilin a promising target in cancer therapy |
| topic | Cyclophilin a PPIase CD147 cell proliferation cell invasion drug resistance |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2425127 |
| work_keys_str_mv | AT shujuanjin cyclophilinapromisingtargetincancertherapy AT mengjiaozhang cyclophilinapromisingtargetincancertherapy AT xiaotingqiao cyclophilinapromisingtargetincancertherapy |