Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study
Background: Older adults remain vulnerable to COVID-19 waves, particularly in low-income countries with health disparities, so the discovery and validation of accessible clinical tools are required. Despite the expected changes associated with aging, little has been studied on ferritinemia as a prog...
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| Format: | Article |
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Elsevier
2024-12-01
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| Series: | Archives of Gerontology and Geriatrics Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950307824001024 |
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| author | Janet Ramírez Torres Ana Luisa Sanchez Arizmendi César J. Serrano Andrade Carlos D. Coronado-Alvarado |
| author_facet | Janet Ramírez Torres Ana Luisa Sanchez Arizmendi César J. Serrano Andrade Carlos D. Coronado-Alvarado |
| author_sort | Janet Ramírez Torres |
| collection | DOAJ |
| description | Background: Older adults remain vulnerable to COVID-19 waves, particularly in low-income countries with health disparities, so the discovery and validation of accessible clinical tools are required. Despite the expected changes associated with aging, little has been studied on ferritinemia as a prognostic marker, specifically in this population. Objective: Evaluate the use of serum ferritin levels at hospital admission as a prognostic marker in older adults hospitalized for COVID-19. Material and methods: This monocentric study included people over 60 hospitalized for COVID-19 between 2021 and 2022. Disease presence was assessed with polymerase chain reaction and ferritin with spectrophotometry. Multiple logistic regression models, as well as ROC and Kaplan-Meier curves, were used. Results: In 239 older adults, the association between serum ferritin and mortality was modified by the presence of clinical severity data at admission, being a poor prognosis factor only for those with severe COVID-19 (OR=2.82, p = 0.028, controlling for age and immunization doses). The best cut-off point was 355 ng/dl (Sensitivity: 88.3 %; Specificity: 27.4 %). However, there were no differences in survival curves. Conclusions: Serum ferritin levels could help guide therapeutic decisions in older adults with severe COVID-19 but do not predict mortality independently. |
| format | Article |
| id | doaj-art-cfcdb443624b44368a4d3da6a397ed56 |
| institution | Kabale University |
| issn | 2950-3078 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Archives of Gerontology and Geriatrics Plus |
| spelling | doaj-art-cfcdb443624b44368a4d3da6a397ed562024-12-13T11:09:49ZengElsevierArchives of Gerontology and Geriatrics Plus2950-30782024-12-0114100105Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort studyJanet Ramírez Torres0Ana Luisa Sanchez Arizmendi1César J. Serrano Andrade2Carlos D. Coronado-Alvarado3Hospital General de Zona #1 del Instituto Mexicano del Seguro Social. Ave. Lapislazuli No. 250, Col. El Haya. CP 28983. Villa de Álvarez, Colima, MexicoHospital General de Zona #1 del Instituto Mexicano del Seguro Social. Ave. Lapislazuli No. 250, Col. El Haya. CP 28983. Villa de Álvarez, Colima, MexicoHospital General de Zona #1 del Instituto Mexicano del Seguro Social. Ave. Lapislazuli No. 250, Col. El Haya. CP 28983. Villa de Álvarez, Colima, MexicoDepartamento de Medicina y Ciencias de la Salud. Universidad de Sonora. Blvd. Luis Encinas y Rosales S/N, Col. Centro, 83000 Hermosillo, Sonora, Mexico; Corresponding author.Background: Older adults remain vulnerable to COVID-19 waves, particularly in low-income countries with health disparities, so the discovery and validation of accessible clinical tools are required. Despite the expected changes associated with aging, little has been studied on ferritinemia as a prognostic marker, specifically in this population. Objective: Evaluate the use of serum ferritin levels at hospital admission as a prognostic marker in older adults hospitalized for COVID-19. Material and methods: This monocentric study included people over 60 hospitalized for COVID-19 between 2021 and 2022. Disease presence was assessed with polymerase chain reaction and ferritin with spectrophotometry. Multiple logistic regression models, as well as ROC and Kaplan-Meier curves, were used. Results: In 239 older adults, the association between serum ferritin and mortality was modified by the presence of clinical severity data at admission, being a poor prognosis factor only for those with severe COVID-19 (OR=2.82, p = 0.028, controlling for age and immunization doses). The best cut-off point was 355 ng/dl (Sensitivity: 88.3 %; Specificity: 27.4 %). However, there were no differences in survival curves. Conclusions: Serum ferritin levels could help guide therapeutic decisions in older adults with severe COVID-19 but do not predict mortality independently.http://www.sciencedirect.com/science/article/pii/S2950307824001024SARS-CoV-2AgedAcute-phase proteinsFerritinsBiomarkersMortality |
| spellingShingle | Janet Ramírez Torres Ana Luisa Sanchez Arizmendi César J. Serrano Andrade Carlos D. Coronado-Alvarado Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study Archives of Gerontology and Geriatrics Plus SARS-CoV-2 Aged Acute-phase proteins Ferritins Biomarkers Mortality |
| title | Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study |
| title_full | Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study |
| title_fullStr | Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study |
| title_full_unstemmed | Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study |
| title_short | Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study |
| title_sort | ferritin at admission as a prognostic marker in older adults hospitalized for covid 19 a retrospective cohort study |
| topic | SARS-CoV-2 Aged Acute-phase proteins Ferritins Biomarkers Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2950307824001024 |
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