Prospective pharmacotyping of urothelial carcinoma organoids for drug sensitivity prediction – feasibility and real world experience

Prospective pharmacotyping of urothelial carcinoma organoids for drug sensitivity prediction – feasibility and real world experience

Abstract Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy. In recent years, patient-derived organoids (PDOs) emerged as a novel tool to model primary tumors with higher resemblance...

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Bibliographic Details
Main Authors: Michael Karl Melzer, Yanchun Ma, Jessica Lindenmayer, Clara Morgenstern, Felix Wezel, Friedemann Zengerling, Cagatay Günes, Nadine Therese Gaisa, Alexander Kleger, Christian Bolenz
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Experimental Hematology & Oncology
Subjects:
Patient-derived organoids
Urothelial carcinoma
Pharmacotyping
Online Access:https://doi.org/10.1186/s40164-024-00579-3
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