The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus
One of the key features of chronic hepatitis B virus (HBV) infection is the inability to mount sufficient and coordinated adaptive immune responses against HBV. Recent studies on HBV-specific B cells and antibody to hepatitis B surface antigen (anti-HBs) have shed light on their role in the pathogen...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2445283 |
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| author | Ling Ding Jiaquan Huang Shuaiwen Huang |
| author_facet | Ling Ding Jiaquan Huang Shuaiwen Huang |
| author_sort | Ling Ding |
| collection | DOAJ |
| description | One of the key features of chronic hepatitis B virus (HBV) infection is the inability to mount sufficient and coordinated adaptive immune responses against HBV. Recent studies on HBV-specific B cells and antibody to hepatitis B surface antigen (anti-HBs) have shed light on their role in the pathogenesis of chronic hepatitis B (CHB). Anti-HBs is recognized as a protective immune marker, both for HBV infection clearance and following vaccination, and it is also considered an important indicator of functional cure for CHB. Notably, functional impairment of HBV-specific B cells may be reversible. The restoration of HBV-specific B cell function, along with the induction of an anti-HBs antibody response, is regarded as pivotal for terminating chronic HBV infection and achieving functional cure. This article reviews the significance of anti-HBs in both the infection and clearance of HBV, and discusses the potential of neutralizing antibodies and therapeutic vaccines as promising future strategies. |
| format | Article |
| id | doaj-art-cfb7af5e559e4f749462291b6fffdc91 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-cfb7af5e559e4f749462291b6fffdc912025-01-04T07:58:17ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2024.2445283The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virusLing Ding0Jiaquan Huang1Shuaiwen Huang2Department of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaOne of the key features of chronic hepatitis B virus (HBV) infection is the inability to mount sufficient and coordinated adaptive immune responses against HBV. Recent studies on HBV-specific B cells and antibody to hepatitis B surface antigen (anti-HBs) have shed light on their role in the pathogenesis of chronic hepatitis B (CHB). Anti-HBs is recognized as a protective immune marker, both for HBV infection clearance and following vaccination, and it is also considered an important indicator of functional cure for CHB. Notably, functional impairment of HBV-specific B cells may be reversible. The restoration of HBV-specific B cell function, along with the induction of an anti-HBs antibody response, is regarded as pivotal for terminating chronic HBV infection and achieving functional cure. This article reviews the significance of anti-HBs in both the infection and clearance of HBV, and discusses the potential of neutralizing antibodies and therapeutic vaccines as promising future strategies.https://www.tandfonline.com/doi/10.1080/21645515.2024.2445283Hepatitis B virushepatitis B surface antibodyfunctional cureHBV-specific B cellstherapeutic vaccines |
| spellingShingle | Ling Ding Jiaquan Huang Shuaiwen Huang The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus Human Vaccines & Immunotherapeutics Hepatitis B virus hepatitis B surface antibody functional cure HBV-specific B cells therapeutic vaccines |
| title | The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus |
| title_full | The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus |
| title_fullStr | The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus |
| title_full_unstemmed | The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus |
| title_short | The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus |
| title_sort | significance of antibody to hepatitis b surface antigen in infection and clearance of hepatitis b virus |
| topic | Hepatitis B virus hepatitis B surface antibody functional cure HBV-specific B cells therapeutic vaccines |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2445283 |
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