Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review
Quorum sensing (QS), an intercellular communication process, depends on the generation, release, and detection of extracellular signaling molecules (autoinducers). Upon binding to their corresponding receptors, these autoinducers activate target genes, regulating various bacterial activities includi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535224004520 |
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| author | Ai-Qun Chen Zhou-Qing Long Ya Xiao Yu-Mei Feng Ya Zhou Shan Yang Yan-Mei Liao Xiang Zhou Li-Wei Liu Zhi-Bing Wu Song Yang |
| author_facet | Ai-Qun Chen Zhou-Qing Long Ya Xiao Yu-Mei Feng Ya Zhou Shan Yang Yan-Mei Liao Xiang Zhou Li-Wei Liu Zhi-Bing Wu Song Yang |
| author_sort | Ai-Qun Chen |
| collection | DOAJ |
| description | Quorum sensing (QS), an intercellular communication process, depends on the generation, release, and detection of extracellular signaling molecules (autoinducers). Upon binding to their corresponding receptors, these autoinducers activate target genes, regulating various bacterial activities including bioluminescence, swimming and swarming motility, symbiosis, protein secretion, plasmid exchange, secondary metabolite production, and biofilm development. Many interactions between plants and microorganisms depend on bacterial QS systems, making them a powerful tool for regulating plant growth and controlling plant pathogens. As QS research deepens, more QS inhibitors (QSIs) emerge, exhibiting diversification. According to its structure, QSIs can be divided into furanone, lactone, substituted Homoserine Lactone (HSL), and Autoinducing Peptide (AIP), further divided into natural products and synthetic products. Natural QSIs primarily originate from animal, plant, and microbial sources. Thereby, QSIs play an important role in plant pathogen control. In order to systematically summarize and extend the application potential of natural product as vital antibacterial active constituent, the mechanisms and applications of natural product-based QSIs in plant pathogen control were discussed and highlighted. We hope this review will provide the comprehensive understanding of the function and underlying action mechanism of natural product-based antimicrobial molecule, and inspire the development of new bactericides targeting QS mechanisms. |
| format | Article |
| id | doaj-art-cfa216557df84f1a9a49abf6d1924bb1 |
| institution | Kabale University |
| issn | 1878-5352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj-art-cfa216557df84f1a9a49abf6d1924bb12024-12-26T08:52:51ZengElsevierArabian Journal of Chemistry1878-53522025-01-01181106050Application of natural product-based quorum sensing inhibitors in plant pathogen control: A reviewAi-Qun Chen0Zhou-Qing Long1Ya Xiao2Yu-Mei Feng3Ya Zhou4Shan Yang5Yan-Mei Liao6Xiang Zhou7Li-Wei Liu8Zhi-Bing Wu9Song Yang10State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaCorresponding authors.; State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaCorresponding authors.; State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaQuorum sensing (QS), an intercellular communication process, depends on the generation, release, and detection of extracellular signaling molecules (autoinducers). Upon binding to their corresponding receptors, these autoinducers activate target genes, regulating various bacterial activities including bioluminescence, swimming and swarming motility, symbiosis, protein secretion, plasmid exchange, secondary metabolite production, and biofilm development. Many interactions between plants and microorganisms depend on bacterial QS systems, making them a powerful tool for regulating plant growth and controlling plant pathogens. As QS research deepens, more QS inhibitors (QSIs) emerge, exhibiting diversification. According to its structure, QSIs can be divided into furanone, lactone, substituted Homoserine Lactone (HSL), and Autoinducing Peptide (AIP), further divided into natural products and synthetic products. Natural QSIs primarily originate from animal, plant, and microbial sources. Thereby, QSIs play an important role in plant pathogen control. In order to systematically summarize and extend the application potential of natural product as vital antibacterial active constituent, the mechanisms and applications of natural product-based QSIs in plant pathogen control were discussed and highlighted. We hope this review will provide the comprehensive understanding of the function and underlying action mechanism of natural product-based antimicrobial molecule, and inspire the development of new bactericides targeting QS mechanisms.http://www.sciencedirect.com/science/article/pii/S1878535224004520Natural productsPlant pathogenic bacteriaAutoinducersQuorum sensing inhibitors |
| spellingShingle | Ai-Qun Chen Zhou-Qing Long Ya Xiao Yu-Mei Feng Ya Zhou Shan Yang Yan-Mei Liao Xiang Zhou Li-Wei Liu Zhi-Bing Wu Song Yang Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review Arabian Journal of Chemistry Natural products Plant pathogenic bacteria Autoinducers Quorum sensing inhibitors |
| title | Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review |
| title_full | Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review |
| title_fullStr | Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review |
| title_full_unstemmed | Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review |
| title_short | Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review |
| title_sort | application of natural product based quorum sensing inhibitors in plant pathogen control a review |
| topic | Natural products Plant pathogenic bacteria Autoinducers Quorum sensing inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S1878535224004520 |
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