Transcriptomic and electrophysiological alterations underlying phenotypic variability in SCN1A-associated febrile seizures

Transcriptomic and electrophysiological alterations underlying phenotypic variability in SCN1A-associated febrile seizures

Abstract Febrile seizures (FS) are a common childhood neurological condition triggered by fever in children without prior neurological disorders. While generally benign, some individuals, particularly those with complex FS or genetic predispositions, may develop epilepsy or other neurological comorb...

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Main Authors: Stefania Scalise, Alessandro Gaeta, Elio Aprigliano, Valeria Lucchino, Raffaele Covello, Mariagrazia Talarico, Barbara Puccio, Pietro Hiram Guzzi, Pierangelo Veltri, Antonio Gambardella, Lilian Juliana Lissner, Alessandra Morano, Pierangelo Cifelli, Veronica Alfano, Eleonora Palma, Gerardo Perozziello, Gabriele Ruffolo, Giovanni Cuda, Elvira Immacolata Parrotta
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Febrile seizure
Mesial temporal lobe epilepsy
Induced pluripotent stem cell-derived neurons
Voltage-gated sodium channel NaV1.1
SCN1A
GABAergic dysfunction
Online Access:https://doi.org/10.1038/s41598-025-09208-3
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