Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice

Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice

Abstract Cancer cells secrete extracellular vesicles (EV) encapsulating bioactive cargoes to facilitate inter-organ communication in vivo and are emerging as critical mediators of tumor progression and metastasis, a condition which is often accompanied by a dysregulated cholesterol metabolism. Wheth...

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Main Authors: Mei-Xin Li, Sheng Hu, He-Hua Lei, Meng Yuan, Xu Li, Wen-Kui Hou, Xiang-Jie Huang, Bing-Wen Xiao, Teng-Xiang Yu, Xiao-Hui Zhang, Xiao-Ting Wu, Wen-Qiang Jing, Hyeon-Jeong Lee, Juan-Juan Li, Da Fu, Li-Min Zhang, Wei Yan
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54706-z
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