Serum CS/DS, IGF-1, and IGFBP-3 as Biomarkers of Cartilage Remodeling in Juvenile Idiopathic Arthritis: Diagnostic and Therapeutic Implications

Serum CS/DS, IGF-1, and IGFBP-3 as Biomarkers of Cartilage Remodeling in Juvenile Idiopathic Arthritis: Diagnostic and Therapeutic Implications

Cartilage destruction in juvenile idiopathic arthritis (JIA) is diagnosed, often too late, on basis of clinical evaluation and radiographic imaging. This case–control study investigated serum chondroitin/dermatan sulfate (CS/DS) as a potential biochemical marker of cartilage metabolism, aiming to im...

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Main Authors: Katarzyna Winsz-Szczotka, Kornelia Kuźnik-Trocha, Ewa M. Koźma, Bogusław Żegleń, Anna Gruenpeter, Grzegorz Wisowski, Katarzyna Komosińska-Vassev, Krystyna Olczyk
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
juvenile idiopathic arthritis
cartilage metabolism
extracellular matrix
chondroitin sulfate
dermatan sulfate
IGF-1/IGFBP-3 axis
Online Access:https://www.mdpi.com/2218-273X/14/12/1526
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https://www.mdpi.com/2218-273X/14/12/1526

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