Elucidating divergent biology in uterine carcinosarcoma

Elucidating divergent biology in uterine carcinosarcoma

Objectives: Uterine carcinosarcoma (UCS) is an aggressive malignancy characterized by epithelial (C) and mesenchymal (S) components, with complex biology and poor treatment response. This study aims to enhance understanding of UCS through genomic, epigenomic, and transcriptomic analysis. Methods: Mi...

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Main Authors: Vikas Garg, Stephenie D. Prokopec, Simone C. Stone, Sara Pakbaz, Min Li Chen, Bernard Lam, Czin Czin Benito, Michelle Mcmullen, Ilinca Lungu, Samanta Del Rossi, Anthony Msan, Valerie Bowering, Valentin Sotov, Christine Tran, Marcus O. Butler, Amit M. Oza, Phedias Diamandis, Ben X. Wang, Stephanie Lheureux
Format: Article
Language:English
Published: Elsevier 2025-11-01
Series:Translational Oncology
Subjects:
Uterine carcinosarcoma
Whole-genome sequencing
Epithelial-to-mesenchymal transition
Multiplex immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325002372
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