Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis
Abstract Objectives Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. This review aimed to identify associations b...
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BMC
2024-11-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-024-03419-1 |
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| author | Stephanie L. Smith Lorna Paul Martijn P. M. Steultjens Rebecca L. Jones |
| author_facet | Stephanie L. Smith Lorna Paul Martijn P. M. Steultjens Rebecca L. Jones |
| author_sort | Stephanie L. Smith |
| collection | DOAJ |
| description | Abstract Objectives Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. This review aimed to identify associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis. Methods A systematic literature review and meta-analysis conducted in PubMed, MEDLINE, CINAHL, EMBASE, Scopus, SPORTDiscus and Web of Science databases from inception to 8th August 2023. Two independent reviewers performed the title, abstract, full-text screening, data extraction and methodological quality assessment. A meta-analysis was undertaken based on the available data. Results Twenty-four studies with 4101 participants with osteoarthritis were included (females: 78%; age range; 49 to 71 years). One study reported muscle-specific biomarkers (n = 3), whilst six studies reported osteoarthritis-specific markers (n = 5). Overall, 93 biomarkers were reported, predominately characterised as inflammatory (n = 35), metabolic (n = 15), and hormones (n = 10). Muscle strength and vitamin D reported a significant association (Hedge’s g: 0.58 (Standard Error (SE): 0.27; P = 0.03), k = 3 studies). Walking speed and high-sensitivity C-reactive protein reported no significant associations (Hedge’s g: -0.02 (SE: 0.05; P = 0.73), k = 3 studies). Conclusion Associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis was limited, the few studies exploring lower limb muscle measures were mainly secondary outcomes. Furthermore, biomarkers were largely related to overall health, with a lack of muscle specific biomarkers. As such, the mechanistic pathways through which these associations occur are less evident, and difficult to draw clear conclusions on these relationships. Trial registration Registered on PROSPERO (CRD42022359405). |
| format | Article |
| id | doaj-art-cf2bca80200a4fa38d7933ae5e63b6a2 |
| institution | Kabale University |
| issn | 1478-6362 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj-art-cf2bca80200a4fa38d7933ae5e63b6a22024-11-10T12:36:12ZengBMCArthritis Research & Therapy1478-63622024-11-0126112010.1186/s13075-024-03419-1Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysisStephanie L. Smith0Lorna Paul1Martijn P. M. Steultjens2Rebecca L. Jones3Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, University of NottinghamResearch Centre for Health (ReaCH), School of Health and Life Sciences, Glasgow Caledonian UniversityResearch Centre for Health (ReaCH), School of Health and Life Sciences, Glasgow Caledonian UniversityHealth Advancement Research Team (HART), School of Sport and Exercise Science, University of LincolnAbstract Objectives Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. This review aimed to identify associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis. Methods A systematic literature review and meta-analysis conducted in PubMed, MEDLINE, CINAHL, EMBASE, Scopus, SPORTDiscus and Web of Science databases from inception to 8th August 2023. Two independent reviewers performed the title, abstract, full-text screening, data extraction and methodological quality assessment. A meta-analysis was undertaken based on the available data. Results Twenty-four studies with 4101 participants with osteoarthritis were included (females: 78%; age range; 49 to 71 years). One study reported muscle-specific biomarkers (n = 3), whilst six studies reported osteoarthritis-specific markers (n = 5). Overall, 93 biomarkers were reported, predominately characterised as inflammatory (n = 35), metabolic (n = 15), and hormones (n = 10). Muscle strength and vitamin D reported a significant association (Hedge’s g: 0.58 (Standard Error (SE): 0.27; P = 0.03), k = 3 studies). Walking speed and high-sensitivity C-reactive protein reported no significant associations (Hedge’s g: -0.02 (SE: 0.05; P = 0.73), k = 3 studies). Conclusion Associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis was limited, the few studies exploring lower limb muscle measures were mainly secondary outcomes. Furthermore, biomarkers were largely related to overall health, with a lack of muscle specific biomarkers. As such, the mechanistic pathways through which these associations occur are less evident, and difficult to draw clear conclusions on these relationships. Trial registration Registered on PROSPERO (CRD42022359405).https://doi.org/10.1186/s13075-024-03419-1Lower limbBiochemical markersMuscle strengthInflammationGeneticsMetabolic |
| spellingShingle | Stephanie L. Smith Lorna Paul Martijn P. M. Steultjens Rebecca L. Jones Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis Arthritis Research & Therapy Lower limb Biochemical markers Muscle strength Inflammation Genetics Metabolic |
| title | Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis |
| title_full | Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis |
| title_fullStr | Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis |
| title_full_unstemmed | Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis |
| title_short | Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis |
| title_sort | associations between biomarkers and skeletal muscle function in individuals with osteoarthritis a systematic review and meta analysis |
| topic | Lower limb Biochemical markers Muscle strength Inflammation Genetics Metabolic |
| url | https://doi.org/10.1186/s13075-024-03419-1 |
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