CCDC69 maintains genome integrity by regulating KIF2C/MCAK depolymerase activity and the stability of the chromosomal passenger complex

CCDC69 maintains genome integrity by regulating KIF2C/MCAK depolymerase activity and the stability of the chromosomal passenger complex

Abstract Accurate genome inheritance during cell division relies on a complex chromosome segregation mechanism. This process occurs once all the kinetochores of sister chromatids are attached to microtubules emanating from the opposite poles of the mitotic spindle. To control the precision of this m...

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Bibliographic Details
Main Authors: Didier Fesquet, Gabriel Rabeharivelo, Juliette van Dijk, Claude Prigent, Nathalie Morin, Sylvie Rouquier
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
CCDC69
Myristoylation
Mitosis
Microtubule dynamics
Chromosomal Passenger Complex
KIF2C/MCAK
Online Access:https://doi.org/10.1038/s41598-024-81022-9
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