Synthesis, structural characterization, in vitro biological evaluation and in silico molecular docking of some new 1,2,3-Benzotriazole-based Schiff base derivatives

Synthesis, structural characterization, in vitro biological evaluation and in silico molecular docking of some new 1,2,3-Benzotriazole-based Schiff base derivatives

1,2,3-benzotriazole-based Schiff base derivatives were synthesized, characterized through different techniques such as 1HNMR, 13CNMR, and HREI-MS, and screened against the alpha-glucosidase enzyme. All the synthesized analogues showed good inhibitory potentials with IC50 values ranging from 2.20 ± 0...

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Bibliographic Details
Main Authors: Shawkat Hayat, Mohamed S. Othman, Hayat Ullah, Amina Qureshi, Fazal Rahim, Sadiqa Begum, Mohsan Nawaz, Abdul Wadood, Amal H. Al-Bagawi, Ahmed M. Aref, Mohamed A. Fareid, Rashid Iqbal
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Results in Chemistry
Subjects:
Alpha-glucosidase
Benzotriazole
Molecular docking study
Synthesis
Schiff base
Structure activity relationship
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625002206
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