Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations
Recent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources (intestinal tract niche) recently, but reports on the isolation region are limited. This study analyzed the differences in the genome of B. bifidum isolated from different geographical populations by...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250243 |
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| author | Min Li Jie Yu Weicheng Li Qiong Wu Jiaqi Sun Zhihong Sun |
| author_facet | Min Li Jie Yu Weicheng Li Qiong Wu Jiaqi Sun Zhihong Sun |
| author_sort | Min Li |
| collection | DOAJ |
| description | Recent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources (intestinal tract niche) recently, but reports on the isolation region are limited. This study analyzed the differences in the genome of B. bifidum isolated from different geographical populations by comparative genomic analysis. Results at the genome level indicated that the GC content of American isolates was significantly higher than that of Chinese and Russian isolates. The phylogenetic tree, based on 919 core genes showed that B. bifidum might be related to the geographical characteristics of isolation region. Furthermore, functional annotation analysis demonstrated that copy numbers of carbohydrate-active enzymes (CAZys) involved in the degradation of polysaccharide from plant and host sources in B. bifidum were high, and 18 CAZys showed significant differences across different geographical populations, indicating that B. bifidum had adapted to the human intestinal environment, especially in the groups with diets rich in fiber. Dietary habits were one of the main reasons for the differences of B. bifidum across different geographical populations. Additionally, B. bifidum exhibited high diversity, evident in glycoside hydrolases, the CRISPR-Cas system, and prophages. This study provides a genetic basis for further research and development of B. bifidum. |
| format | Article |
| id | doaj-art-cee3d19db0b343f097ac7cfeb7645e9e |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-cee3d19db0b343f097ac7cfeb7645e9e2025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011353006301710.26599/FSHW.2022.9250243Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populationsMin Li0Jie Yu1Weicheng Li2Qiong Wu3Jiaqi Sun4Zhihong Sun5Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaRecent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources (intestinal tract niche) recently, but reports on the isolation region are limited. This study analyzed the differences in the genome of B. bifidum isolated from different geographical populations by comparative genomic analysis. Results at the genome level indicated that the GC content of American isolates was significantly higher than that of Chinese and Russian isolates. The phylogenetic tree, based on 919 core genes showed that B. bifidum might be related to the geographical characteristics of isolation region. Furthermore, functional annotation analysis demonstrated that copy numbers of carbohydrate-active enzymes (CAZys) involved in the degradation of polysaccharide from plant and host sources in B. bifidum were high, and 18 CAZys showed significant differences across different geographical populations, indicating that B. bifidum had adapted to the human intestinal environment, especially in the groups with diets rich in fiber. Dietary habits were one of the main reasons for the differences of B. bifidum across different geographical populations. Additionally, B. bifidum exhibited high diversity, evident in glycoside hydrolases, the CRISPR-Cas system, and prophages. This study provides a genetic basis for further research and development of B. bifidum.https://www.sciopen.com/article/10.26599/FSHW.2022.9250243bifidobacterium bifidumcomparative genomicsgenetic diversityadaptationcarbohydrate-active enzymes |
| spellingShingle | Min Li Jie Yu Weicheng Li Qiong Wu Jiaqi Sun Zhihong Sun Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations Food Science and Human Wellness bifidobacterium bifidum comparative genomics genetic diversity adaptation carbohydrate-active enzymes |
| title | Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations |
| title_full | Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations |
| title_fullStr | Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations |
| title_full_unstemmed | Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations |
| title_short | Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations |
| title_sort | comparative genomic analysis revealed that dietary habits affected the adaptation of bifidobacterium bifidum to the intestinal tract in different geographic populations |
| topic | bifidobacterium bifidum comparative genomics genetic diversity adaptation carbohydrate-active enzymes |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250243 |
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