Nepal Family Cohort study: a study protocol
Introduction The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children’s and their parents’ environmental, behavioural and metabolic risk factors. These factors can affect the overall development of children to adulthood and the onset of spec...
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BMJ Publishing Group
2024-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/11/e088896.full |
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| author | Harpal Randeva Derrick Bennett Charlotte E Bolton Paramjit Gill Anders Løkke Peter Phiri Pramod R Regmi Edwin van Teijlingen Puspa Raj Pant Kin Bong Hubert Lam Padam Simkhada Ioannis Kyrou Gayathri Delanerolle Ashish Shetty John Balmes Adnan Custovic Vanora Hundley Imran Satia Nagendra Chaudhary Tara Ballav Adhikari Om P. Kurmi Sanjivan Gautam Prashil Raj Dali Paul O'Byrne Rajendra Pangeni Milan Bimali Dipak Uprety Jian Shi Qing Ashesh Dhungana John Hurst Balram Gautam Jagat Jeevan Ghimire Sudhir Kumar Tyagi Satyendra Upadhyay Tara Kanta Sigdel |
| author_facet | Harpal Randeva Derrick Bennett Charlotte E Bolton Paramjit Gill Anders Løkke Peter Phiri Pramod R Regmi Edwin van Teijlingen Puspa Raj Pant Kin Bong Hubert Lam Padam Simkhada Ioannis Kyrou Gayathri Delanerolle Ashish Shetty John Balmes Adnan Custovic Vanora Hundley Imran Satia Nagendra Chaudhary Tara Ballav Adhikari Om P. Kurmi Sanjivan Gautam Prashil Raj Dali Paul O'Byrne Rajendra Pangeni Milan Bimali Dipak Uprety Jian Shi Qing Ashesh Dhungana John Hurst Balram Gautam Jagat Jeevan Ghimire Sudhir Kumar Tyagi Satyendra Upadhyay Tara Kanta Sigdel |
| collection | DOAJ |
| description | Introduction The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children’s and their parents’ environmental, behavioural and metabolic risk factors. These factors can affect the overall development of children to adulthood and the onset of specific diseases. Among the many risk factors, exposure to air pollution and lifestyle factors during childhood may impact lung development and function, leading to the early onset of respiratory diseases. The global incidence and prevalence of respiratory diseases are rapidly increasing, with the rate of increase in Nepal being the highest. Although the cohort will primarily focus on respiratory health, other health outcomes such as cardiovascular, metabolic and mental health will be assessed to provide a comprehensive overall health assessment. All other health outcomes are self-reported following doctor diagnosis. Some of these health outcomes will be quality controlled during the follow-up by measuring disease specific markers. Our cohort study will likely provide evidence of risk factors and policy recommendations.Methods and analysis Using a life-course epidemiology approach, we established a longitudinal study to address the determinants of lung health and other health outcomes from childhood to adulthood. The baseline data collection (personal data anonymised) was completed in April 2024, and 16 826 participants (9225 children and 7601 parents) from 5829 families were recruited in different geographical and climate areas (hills and plains) of Nepal. We plan to follow up all the participants every 2–3 years.Descriptive analysis will be used to report demographic characteristics and compare rural and semi-urban regions. A linear regression model will assess the association between air pollution, particularly household air pollution (HAP) exposure, and other lifestyle factors, with lung function adjusted for potential confounders. A two-stage linear regression model will help to evaluate lung development based on exposure to HAP.Ethics Ethical approval was obtained from the Nepal Health Research Council, Kathmandu, Nepal, and McMaster University, Hamilton, Canada. Permissions were obtained from two municipalities where the study sites are located. Parents provided signed informed consent and children their assent.Dissemination Findings will be disseminated through traditional academic pathways, including peer-reviewed publications and conference presentations. We will also engage the study population and local media (ie, research blogs and dissemination events) and prepare research and policy briefings for stakeholders and leaders at the local, provincial and national levels. |
| format | Article |
| id | doaj-art-cee0646bda9b4e738e9a3ee1728dbb60 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-cee0646bda9b4e738e9a3ee1728dbb602024-11-12T19:15:09ZengBMJ Publishing GroupBMJ Open2044-60552024-11-01141110.1136/bmjopen-2024-088896Nepal Family Cohort study: a study protocol Harpal Randeva0Derrick Bennett1Charlotte E Bolton2Paramjit Gill3Anders Løkke4Peter PhiriPramod R Regmi5Edwin van Teijlingen6Puspa Raj Pant7Kin Bong Hubert Lam8Padam Simkhada9Ioannis Kyrou10Gayathri Delanerolle11Ashish ShettyJohn BalmesAdnan Custovic12Vanora Hundley13Imran Satia14Nagendra Chaudhary15Tara Ballav AdhikariOm P. Kurmi16Sanjivan Gautam17Prashil Raj Dali18Paul O'Byrne19Rajendra PangeniMilan BimaliDipak UpretyJian Shi QingAshesh DhunganaJohn HurstBalram GautamJagat Jeevan GhimireSudhir Kumar TyagiSatyendra UpadhyayTara Kanta Sigdel2017 Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK14 Nuffield Department of Population Health, University of Oxford, Oxford, UK7 NIHR Nottingham Biomedical Research Centre, Nottingham, UK16 Warwick Centre for Global Health, University of Warwick, Coventry, UK13 Lung Department, B, Aarhus University Hospital, Aarhus C, Denmark9 Faculty of Health and Social Sciences, Bournemouth University, Bournemouth, UK12 Centre for Midwifery & Women`s Health, Bournemouth University, Bournemouth, UK3 Nexus Institute of Research and Innovation, Lalitpur, Nepal14 Nuffield Department of Population Health, University of Oxford, Oxford, UK10 School of Human and Health Sciences, University of Huddersfield, Huddersfield, UK11 WISDEM Centre, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK5 University of Birmingham, Birmingham, UK15 Imperial College London, London, UK12 Centre for Midwifery & Women`s Health, Bournemouth University, Bournemouth, UK2 Department of Medicine, McMaster University, Hamilton, Ontario, Canada4 Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal1 Centre for Healthcare and Communities, Coventry University, Coventry, UK3 Nexus Institute of Research and Innovation, Lalitpur, Nepal3 Nexus Institute of Research and Innovation, Lalitpur, Nepal2 Department of Medicine, McMaster University, Hamilton, Ontario, Canada3 Nexus Institute of Research and Innovation, Lalitpur, NepalIntroduction The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children’s and their parents’ environmental, behavioural and metabolic risk factors. These factors can affect the overall development of children to adulthood and the onset of specific diseases. Among the many risk factors, exposure to air pollution and lifestyle factors during childhood may impact lung development and function, leading to the early onset of respiratory diseases. The global incidence and prevalence of respiratory diseases are rapidly increasing, with the rate of increase in Nepal being the highest. Although the cohort will primarily focus on respiratory health, other health outcomes such as cardiovascular, metabolic and mental health will be assessed to provide a comprehensive overall health assessment. All other health outcomes are self-reported following doctor diagnosis. Some of these health outcomes will be quality controlled during the follow-up by measuring disease specific markers. Our cohort study will likely provide evidence of risk factors and policy recommendations.Methods and analysis Using a life-course epidemiology approach, we established a longitudinal study to address the determinants of lung health and other health outcomes from childhood to adulthood. The baseline data collection (personal data anonymised) was completed in April 2024, and 16 826 participants (9225 children and 7601 parents) from 5829 families were recruited in different geographical and climate areas (hills and plains) of Nepal. We plan to follow up all the participants every 2–3 years.Descriptive analysis will be used to report demographic characteristics and compare rural and semi-urban regions. A linear regression model will assess the association between air pollution, particularly household air pollution (HAP) exposure, and other lifestyle factors, with lung function adjusted for potential confounders. A two-stage linear regression model will help to evaluate lung development based on exposure to HAP.Ethics Ethical approval was obtained from the Nepal Health Research Council, Kathmandu, Nepal, and McMaster University, Hamilton, Canada. Permissions were obtained from two municipalities where the study sites are located. Parents provided signed informed consent and children their assent.Dissemination Findings will be disseminated through traditional academic pathways, including peer-reviewed publications and conference presentations. We will also engage the study population and local media (ie, research blogs and dissemination events) and prepare research and policy briefings for stakeholders and leaders at the local, provincial and national levels.https://bmjopen.bmj.com/content/14/11/e088896.full |
| spellingShingle | Harpal Randeva Derrick Bennett Charlotte E Bolton Paramjit Gill Anders Løkke Peter Phiri Pramod R Regmi Edwin van Teijlingen Puspa Raj Pant Kin Bong Hubert Lam Padam Simkhada Ioannis Kyrou Gayathri Delanerolle Ashish Shetty John Balmes Adnan Custovic Vanora Hundley Imran Satia Nagendra Chaudhary Tara Ballav Adhikari Om P. Kurmi Sanjivan Gautam Prashil Raj Dali Paul O'Byrne Rajendra Pangeni Milan Bimali Dipak Uprety Jian Shi Qing Ashesh Dhungana John Hurst Balram Gautam Jagat Jeevan Ghimire Sudhir Kumar Tyagi Satyendra Upadhyay Tara Kanta Sigdel Nepal Family Cohort study: a study protocol BMJ Open |
| title | Nepal Family Cohort study: a study protocol |
| title_full | Nepal Family Cohort study: a study protocol |
| title_fullStr | Nepal Family Cohort study: a study protocol |
| title_full_unstemmed | Nepal Family Cohort study: a study protocol |
| title_short | Nepal Family Cohort study: a study protocol |
| title_sort | nepal family cohort study a study protocol |
| url | https://bmjopen.bmj.com/content/14/11/e088896.full |
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