Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study
Background No study explored the association of noise exposure in the workplace and genetic susceptibility with incidence of atrial fibrillation (AF). We aimed to assess the separate and joint relationship of noise exposure in the workplace and genetic susceptibility with the risk of AF. Methods and...
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Wiley
2024-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.036543 |
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| author | Wenzhen Li Junjie Zhu Xingjie Hao Zhaomin Chen Dongming Wang |
| author_facet | Wenzhen Li Junjie Zhu Xingjie Hao Zhaomin Chen Dongming Wang |
| author_sort | Wenzhen Li |
| collection | DOAJ |
| description | Background No study explored the association of noise exposure in the workplace and genetic susceptibility with incidence of atrial fibrillation (AF). We aimed to assess the separate and joint relationship of noise exposure in the workplace and genetic susceptibility with the risk of AF. Methods and Results We included 167 577 participants without AF at baseline in UK Biobank. Cox proportional hazards models were used to assess the separate and joint association of noise exposure in the workplace and genetic susceptibility with the risk of AF. During a median follow‐up of 11.83 years, we observed 9355 AF cases. Compared with no noise exposure in the workplace, the hazard ratios (HRs) and were 1.08 (95% CI, 0.99–1.18) for noise exposure in the workplace of <1 year, 1.03 (95% CI, 0.95–1.12) for noise exposure in the workplace of around 1 to 5 years, and 1.08 (95% CI, 1.02–1.14) for noise exposure in the workplace of >5 years, respectively, after adjusting for potential confounders. Genetic risk was positively associated with AF, compared with low genetic risk (tertile 1), the HRs were 1.50 (95% CI, 1.41–1.59) for medium genetic risk (tertile 2) and 2.51 (95% CI, 2.38–2.65) for high genetic risk (tertile 3). However, no interaction between noise exposure in the workplace and genetic susceptibility was observed (P>0.05). Conclusions Long‐term noise exposure in the workplace is positively associated with a higher incidence of AF regardless of genetic background. |
| format | Article |
| id | doaj-art-ce92a29f3c9441f99ce751c52be9d75d |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-ce92a29f3c9441f99ce751c52be9d75d2024-11-29T09:50:51ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-11-01132110.1161/JAHA.124.036543Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort StudyWenzhen Li0Junjie Zhu1Xingjie Hao2Zhaomin Chen3Dongming Wang4Department of Occupational & Environmental Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Health Statistics, School of Public Health Dali University Dali Yunnan ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational & Environmental Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational & Environmental Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei ChinaBackground No study explored the association of noise exposure in the workplace and genetic susceptibility with incidence of atrial fibrillation (AF). We aimed to assess the separate and joint relationship of noise exposure in the workplace and genetic susceptibility with the risk of AF. Methods and Results We included 167 577 participants without AF at baseline in UK Biobank. Cox proportional hazards models were used to assess the separate and joint association of noise exposure in the workplace and genetic susceptibility with the risk of AF. During a median follow‐up of 11.83 years, we observed 9355 AF cases. Compared with no noise exposure in the workplace, the hazard ratios (HRs) and were 1.08 (95% CI, 0.99–1.18) for noise exposure in the workplace of <1 year, 1.03 (95% CI, 0.95–1.12) for noise exposure in the workplace of around 1 to 5 years, and 1.08 (95% CI, 1.02–1.14) for noise exposure in the workplace of >5 years, respectively, after adjusting for potential confounders. Genetic risk was positively associated with AF, compared with low genetic risk (tertile 1), the HRs were 1.50 (95% CI, 1.41–1.59) for medium genetic risk (tertile 2) and 2.51 (95% CI, 2.38–2.65) for high genetic risk (tertile 3). However, no interaction between noise exposure in the workplace and genetic susceptibility was observed (P>0.05). Conclusions Long‐term noise exposure in the workplace is positively associated with a higher incidence of AF regardless of genetic background.https://www.ahajournals.org/doi/10.1161/JAHA.124.036543atrial fibrillationgenetic susceptibilitynoise exposureworkplace |
| spellingShingle | Wenzhen Li Junjie Zhu Xingjie Hao Zhaomin Chen Dongming Wang Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atrial fibrillation genetic susceptibility noise exposure workplace |
| title | Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study |
| title_full | Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study |
| title_fullStr | Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study |
| title_full_unstemmed | Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study |
| title_short | Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study |
| title_sort | noise exposure in the workplace genetic susceptibility and incidence of atrial fibrillation a prospective cohort study |
| topic | atrial fibrillation genetic susceptibility noise exposure workplace |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.036543 |
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