Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect
BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involve...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Eco-Vector
2025-04-01
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| Series: | Consortium Psychiatricum |
| Subjects: | |
| Online Access: | https://consortium-psy.com/jour/article/viewFile/15563/pdf |
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| Summary: | BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature.
CASE REPORT: The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement.
CONCLUSION: Сhlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE. |
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| ISSN: | 2712-7672 2713-2919 |