Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders
Fluorodeoxyglucose F18 (FDG) positron emission tomography (PET) imaging can help clinicians pursue the differential diagnosis of various neurodegenerative diseases. It has become an invaluable diagnostic tool in routine clinical practice in conjunction with computed tomography (CT) imaging, magnetic...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1428036/full |
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| author | Brendan Huang Sara Sawicki Sara Sawicki Carolyn Habiger Carolyn Habiger Paul J. Mattis Marc L. Gordon Marc L. Gordon Ana M. Franceschi Luca Giliberto Luca Giliberto |
| author_facet | Brendan Huang Sara Sawicki Sara Sawicki Carolyn Habiger Carolyn Habiger Paul J. Mattis Marc L. Gordon Marc L. Gordon Ana M. Franceschi Luca Giliberto Luca Giliberto |
| author_sort | Brendan Huang |
| collection | DOAJ |
| description | Fluorodeoxyglucose F18 (FDG) positron emission tomography (PET) imaging can help clinicians pursue the differential diagnosis of various neurodegenerative diseases. It has become an invaluable diagnostic tool in routine clinical practice in conjunction with computed tomography (CT) imaging, magnetic resonance imaging (MRI), and biomarker studies. We present a single-institution case series and systematic literature review, showing how FDG-PET imaging has helped physicians diagnose neurodegenerative diseases and their mimickers and how patient care was amended. A single institution analysis and comprehensive literature search were completed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. These medical subjects’ headings (MeSH) terms were used: “FDG-PET” AND “dementia” OR “Alzheimer’s” OR “neurodegeneration” OR “frontotemporal dementia” OR “atypical parkinsonian syndrome” OR “primary progressive aphasia” OR “lewy body dementia.” The inclusion criteria included studies with uncertain diagnoses of neurocognitive disease resolved with FDG-PET, PET/MRI, or PET/CT hybrid imaging. A literature search resulted in 3,976 articles. After considering inclusion and exclusion criteria, 14 case reports and 1 case series were selected, representing 19 patients. The average age of patients was 70.8 years (range: 54–83 years). Five of the 19 patients were females. Dementia with Lewy bodies (DLB) had the highest propensity for being misidentified as another neurodegenerative disease, followed by Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Without accurate molecular imaging, neurodegenerative diseases may be missed or misdiagnosed. Our single-institution case series and literature review demonstrate how FDG-PET brain imaging can be used to correct and clarify preexisting clinical diagnoses of neurodegenerative disease. |
| format | Article |
| id | doaj-art-ce66fa433dc84e61b436617bee122b51 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-ce66fa433dc84e61b436617bee122b512024-11-19T06:15:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-11-011510.3389/fneur.2024.14280361428036Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disordersBrendan Huang0Sara Sawicki1Sara Sawicki2Carolyn Habiger3Carolyn Habiger4Paul J. Mattis5Marc L. Gordon6Marc L. Gordon7Ana M. Franceschi8Luca Giliberto9Luca Giliberto10Department of Neurology, Northwell, New Hyde Park, NY, United StatesDepartment of Neurology, Northwell, New Hyde Park, NY, United StatesZucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesDepartment of Neurology, Northwell, New Hyde Park, NY, United StatesZucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesDepartment of Psychiatry, Northwell, New Hyde Park, NY, United StatesDepartments of Neurology and Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesFeinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesDepartment of Radiology, Northwell, New Hyde Park, NY, United StatesDepartment of Neurology, Northwell, New Hyde Park, NY, United StatesFeinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesFluorodeoxyglucose F18 (FDG) positron emission tomography (PET) imaging can help clinicians pursue the differential diagnosis of various neurodegenerative diseases. It has become an invaluable diagnostic tool in routine clinical practice in conjunction with computed tomography (CT) imaging, magnetic resonance imaging (MRI), and biomarker studies. We present a single-institution case series and systematic literature review, showing how FDG-PET imaging has helped physicians diagnose neurodegenerative diseases and their mimickers and how patient care was amended. A single institution analysis and comprehensive literature search were completed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. These medical subjects’ headings (MeSH) terms were used: “FDG-PET” AND “dementia” OR “Alzheimer’s” OR “neurodegeneration” OR “frontotemporal dementia” OR “atypical parkinsonian syndrome” OR “primary progressive aphasia” OR “lewy body dementia.” The inclusion criteria included studies with uncertain diagnoses of neurocognitive disease resolved with FDG-PET, PET/MRI, or PET/CT hybrid imaging. A literature search resulted in 3,976 articles. After considering inclusion and exclusion criteria, 14 case reports and 1 case series were selected, representing 19 patients. The average age of patients was 70.8 years (range: 54–83 years). Five of the 19 patients were females. Dementia with Lewy bodies (DLB) had the highest propensity for being misidentified as another neurodegenerative disease, followed by Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Without accurate molecular imaging, neurodegenerative diseases may be missed or misdiagnosed. Our single-institution case series and literature review demonstrate how FDG-PET brain imaging can be used to correct and clarify preexisting clinical diagnoses of neurodegenerative disease.https://www.frontiersin.org/articles/10.3389/fneur.2024.1428036/fullAlzheimer’s diseaselewy body dementiaFDG-PETfrontotemporal dementiasystematic review |
| spellingShingle | Brendan Huang Sara Sawicki Sara Sawicki Carolyn Habiger Carolyn Habiger Paul J. Mattis Marc L. Gordon Marc L. Gordon Ana M. Franceschi Luca Giliberto Luca Giliberto Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders Frontiers in Neurology Alzheimer’s disease lewy body dementia FDG-PET frontotemporal dementia systematic review |
| title | Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders |
| title_full | Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders |
| title_fullStr | Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders |
| title_full_unstemmed | Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders |
| title_short | Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders |
| title_sort | memories and mimics unveiling the potential of fdg pet in guiding therapeutic approaches for neurodegenerative cognitive disorders |
| topic | Alzheimer’s disease lewy body dementia FDG-PET frontotemporal dementia systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1428036/full |
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