Intestinal permeability, food antigens and the microbiome: a multifaceted perspective
The gut barrier encompasses several interactive, physical, and functional components, such as the gut microbiota, the mucus layer, the epithelial layer and the gut mucosal immunity. All these contribute to homeostasis in a well-regulated manner. Nevertheless, this frail balance might be disrupted fo...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2024.1505834/full |
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| author | Francesco Valitutti Francesco Valitutti Maurizio Mennini Gianluca Monacelli Giulia Fagiolari Marisa Piccirillo Giovanni Di Nardo Giuseppe Di Cara |
| author_facet | Francesco Valitutti Francesco Valitutti Maurizio Mennini Gianluca Monacelli Giulia Fagiolari Marisa Piccirillo Giovanni Di Nardo Giuseppe Di Cara |
| author_sort | Francesco Valitutti |
| collection | DOAJ |
| description | The gut barrier encompasses several interactive, physical, and functional components, such as the gut microbiota, the mucus layer, the epithelial layer and the gut mucosal immunity. All these contribute to homeostasis in a well-regulated manner. Nevertheless, this frail balance might be disrupted for instance by westernized dietary habits, infections, pollution or exposure to antibiotics, thus diminishing protective immunity and leading to the onset of chronic diseases. Several gaps of knowledge still exist as regards this multi-level interaction. In this review we aim to summarize current evidence linking food antigens, microbiota and gut permeability interference in diverse disease conditions such as celiac disease (CeD), non-celiac wheat sensitivity (NCWS), food allergies (FA), eosinophilic gastrointestinal disorder (EOGID) and irritable bowel syndrome (IBS). Specific food elimination diets are recommended for CeD, NCWS, FA and in some cases for EOGID. Undoubtfully, each of these conditions is very different and quite unique, albeit food antigens/compounds, intestinal permeability and specific microbiota signatures orchestrate immune response and decide clinical outcomes for all of them. |
| format | Article |
| id | doaj-art-ce4aab89f29740f0b14210728b3e0f80 |
| institution | Kabale University |
| issn | 2673-6101 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj-art-ce4aab89f29740f0b14210728b3e0f802025-01-09T06:10:47ZengFrontiers Media S.A.Frontiers in Allergy2673-61012025-01-01510.3389/falgy.2024.15058341505834Intestinal permeability, food antigens and the microbiome: a multifaceted perspectiveFrancesco Valitutti0Francesco Valitutti1Maurizio Mennini2Gianluca Monacelli3Giulia Fagiolari4Marisa Piccirillo5Giovanni Di Nardo6Giuseppe Di Cara7Department of Medicine and Surgery, Pediatric Unit, University of Perugia, Perugia, ItalyEuropean Biomedical Research Institute of Salerno (EBRIS), Salerno, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, ItalyDepartment of Medicine and Surgery, Pediatric Unit, University of Perugia, Perugia, ItalyDepartment of Medicine and Surgery, Pediatric Unit, University of Perugia, Perugia, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, ItalyDepartment of Medicine and Surgery, Pediatric Unit, University of Perugia, Perugia, ItalyThe gut barrier encompasses several interactive, physical, and functional components, such as the gut microbiota, the mucus layer, the epithelial layer and the gut mucosal immunity. All these contribute to homeostasis in a well-regulated manner. Nevertheless, this frail balance might be disrupted for instance by westernized dietary habits, infections, pollution or exposure to antibiotics, thus diminishing protective immunity and leading to the onset of chronic diseases. Several gaps of knowledge still exist as regards this multi-level interaction. In this review we aim to summarize current evidence linking food antigens, microbiota and gut permeability interference in diverse disease conditions such as celiac disease (CeD), non-celiac wheat sensitivity (NCWS), food allergies (FA), eosinophilic gastrointestinal disorder (EOGID) and irritable bowel syndrome (IBS). Specific food elimination diets are recommended for CeD, NCWS, FA and in some cases for EOGID. Undoubtfully, each of these conditions is very different and quite unique, albeit food antigens/compounds, intestinal permeability and specific microbiota signatures orchestrate immune response and decide clinical outcomes for all of them.https://www.frontiersin.org/articles/10.3389/falgy.2024.1505834/fullintestinal permeabilitygut barrierceliac diseasefood allergyeosinophilic gastrointestinal disordersirritable bowel syndrome |
| spellingShingle | Francesco Valitutti Francesco Valitutti Maurizio Mennini Gianluca Monacelli Giulia Fagiolari Marisa Piccirillo Giovanni Di Nardo Giuseppe Di Cara Intestinal permeability, food antigens and the microbiome: a multifaceted perspective Frontiers in Allergy intestinal permeability gut barrier celiac disease food allergy eosinophilic gastrointestinal disorders irritable bowel syndrome |
| title | Intestinal permeability, food antigens and the microbiome: a multifaceted perspective |
| title_full | Intestinal permeability, food antigens and the microbiome: a multifaceted perspective |
| title_fullStr | Intestinal permeability, food antigens and the microbiome: a multifaceted perspective |
| title_full_unstemmed | Intestinal permeability, food antigens and the microbiome: a multifaceted perspective |
| title_short | Intestinal permeability, food antigens and the microbiome: a multifaceted perspective |
| title_sort | intestinal permeability food antigens and the microbiome a multifaceted perspective |
| topic | intestinal permeability gut barrier celiac disease food allergy eosinophilic gastrointestinal disorders irritable bowel syndrome |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2024.1505834/full |
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