Assessment of dermal sensitization by nickel salts in a novel humanized TLR-4 mouse model

Assessment of dermal sensitization by nickel salts in a novel humanized TLR-4 mouse model

The fundamental goal of this study was to determine the potential utility of a novel humanized Toll-like receptor-4 (hTLR-4) mouse model for future in vivo studies of nickel allergy. First, mice of both sexes and hTLR-4 expression profiles were incorporated into a Local Lymph Node Assay (LLNA) to as...

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Bibliographic Details
Main Authors: K. A. Roach, S. E. Anderson, C. Waggy, J. Aldinger, A. B. Stefaniak, J. R. Roberts
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Immunotoxicology
Subjects:
Nickel
toll-like receptor-4
local lymph node assay
hypersensitivity
allergy model
sensitization
Online Access:https://www.tandfonline.com/doi/10.1080/1547691X.2024.2414979
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