Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico
Introduction Hyperthermia (HT) induces various cellular biological processes, such as repair impairment and direct HT cell killing. In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2320852 |
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| author | Sergio Mingo Barba Adela Ademaj Dietmar Marder Oliver Riesterer Marco Lattuada Rudolf M. Füchslin Alke Petri-Fink Stephan Scheidegger |
| author_facet | Sergio Mingo Barba Adela Ademaj Dietmar Marder Oliver Riesterer Marco Lattuada Rudolf M. Füchslin Alke Petri-Fink Stephan Scheidegger |
| author_sort | Sergio Mingo Barba |
| collection | DOAJ |
| description | Introduction Hyperthermia (HT) induces various cellular biological processes, such as repair impairment and direct HT cell killing. In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions.Methods An extended linear-quadratic model calibrated for SiHa and HeLa cell lines (cervical cancer) was used to theoretically study the impact of varying HT treatment conditions on radiosensitization and direct HT cell killing effect. Simulated patients were generated to compute the Tumor Control Probability (TCP) under different HT conditions (number of HT sessions, temperature and time interval), which were randomly selected within margins based on reported patient data.Results Under the studied conditions, model-based simulations suggested a treatment improvement with a total CEM43 thermal dose of approximately 10 min. Additionally, for a given thermal dose, TCP increased with the number of HT sessions. Furthermore, in the simulations, we showed that the TCP dependence on the temperature/time interval is more correlated with the mean value than with the minimum/maximum value and that comparing the treatment outcome with the mean temperature can be an excellent strategy for studying the time interval effect.Conclusion The use of thermoradiobiological models allows us to theoretically study the impact of varying thermal conditions on HT + RT treatment outcomes. This approach can be used to optimize HT treatments, design clinical trials, and interpret patient data. |
| format | Article |
| id | doaj-art-ce25e1db2ce54d5c87320b8b31311a0c |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-ce25e1db2ce54d5c87320b8b31311a0c2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2320852Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silicoSergio Mingo Barba0Adela Ademaj1Dietmar Marder2Oliver Riesterer3Marco Lattuada4Rudolf M. Füchslin5Alke Petri-Fink6Stephan Scheidegger7School of Engineering, Zürich University of Applied Sciences (ZHAW), Winterthur, SwitzerlandCenter for Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, SwitzerlandCenter for Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, SwitzerlandCenter for Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, SwitzerlandChemistry Department, University of Fribourg, Fribourg, SwitzerlandSchool of Engineering, Zürich University of Applied Sciences (ZHAW), Winterthur, SwitzerlandChemistry Department, University of Fribourg, Fribourg, SwitzerlandSchool of Engineering, Zürich University of Applied Sciences (ZHAW), Winterthur, SwitzerlandIntroduction Hyperthermia (HT) induces various cellular biological processes, such as repair impairment and direct HT cell killing. In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions.Methods An extended linear-quadratic model calibrated for SiHa and HeLa cell lines (cervical cancer) was used to theoretically study the impact of varying HT treatment conditions on radiosensitization and direct HT cell killing effect. Simulated patients were generated to compute the Tumor Control Probability (TCP) under different HT conditions (number of HT sessions, temperature and time interval), which were randomly selected within margins based on reported patient data.Results Under the studied conditions, model-based simulations suggested a treatment improvement with a total CEM43 thermal dose of approximately 10 min. Additionally, for a given thermal dose, TCP increased with the number of HT sessions. Furthermore, in the simulations, we showed that the TCP dependence on the temperature/time interval is more correlated with the mean value than with the minimum/maximum value and that comparing the treatment outcome with the mean temperature can be an excellent strategy for studying the time interval effect.Conclusion The use of thermoradiobiological models allows us to theoretically study the impact of varying thermal conditions on HT + RT treatment outcomes. This approach can be used to optimize HT treatments, design clinical trials, and interpret patient data.https://www.tandfonline.com/doi/10.1080/02656736.2024.2320852Hyperthermiaradiotherapybiological modelingtreatment conditionstumor control probability |
| spellingShingle | Sergio Mingo Barba Adela Ademaj Dietmar Marder Oliver Riesterer Marco Lattuada Rudolf M. Füchslin Alke Petri-Fink Stephan Scheidegger Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico International Journal of Hyperthermia Hyperthermia radiotherapy biological modeling treatment conditions tumor control probability |
| title | Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico |
| title_full | Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico |
| title_fullStr | Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico |
| title_full_unstemmed | Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico |
| title_short | Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico |
| title_sort | theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability tcp of simulated cervical cancer hyperthermia radiotherapy ht rt treatments in silico |
| topic | Hyperthermia radiotherapy biological modeling treatment conditions tumor control probability |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2320852 |
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