Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy

Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy

Abstract Loss of β‐cell number and function is a hallmark of diabetes. β‐cell preservation is emerging as a promising strategy to treat and reverse diabetes. Here, we first found that Pdia4 was primarily expressed in β‐cells. This expression was up‐regulated in β‐cells and blood of mice in response...

Full description

Saved in:
Bibliographic Details
Main Authors: Tien‐Fen Kuo, Shuo‐Wen Hsu, Shou‐Hsien Huang, Cicero Lee‐Tian Chang, Ching‐Shan Feng, Ming‐Guang Huang, Tzung‐Yan Chen, Meng‐Ting Yang, Si‐Tse Jiang, Tuan‐Nan Wen, Chun‐Yen Yang, Chung‐Yu Huang, Shu‐Huei Kao, Keng‐Chang Tsai, Greta Yang, Wen‐Chin Yang
Format: Article
Language:English
Published: Springer Nature 2021-09-01
Series:EMBO Molecular Medicine
Subjects:
diabetes
Pdia4
ROS
β‐cell failure
β‐cells
Online Access:https://doi.org/10.15252/emmm.201911668
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.15252/emmm.201911668

Similar Items