Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia
Background: This study aims to investigate the levels of interleukin6(IL6), interleukin 10(IL10), the IL6:IL10 ratio, and various anthropometric measurements in different stages of sarcopenia among older individuals. Methodology: Conducted as a one-year cross-sectional study using purposive sampling...
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| Format: | Article |
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Elsevier
2024-09-01
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| Series: | Archives of Gerontology and Geriatrics Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950307824000432 |
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| author | Sharon P Rose Anju Srinivas Akila Prashant Prathiba Periera Suma M Nataraj Kusuma K Shivashankar |
| author_facet | Sharon P Rose Anju Srinivas Akila Prashant Prathiba Periera Suma M Nataraj Kusuma K Shivashankar |
| author_sort | Sharon P Rose |
| collection | DOAJ |
| description | Background: This study aims to investigate the levels of interleukin6(IL6), interleukin 10(IL10), the IL6:IL10 ratio, and various anthropometric measurements in different stages of sarcopenia among older individuals. Methodology: Conducted as a one-year cross-sectional study using purposive sampling, involving individuals aged 58–85 years, screened for sarcopenia based on the AWGS-2019 criteria. Case-finding methods included the SARCCalF questionnaire, handgrip strength(HGS), and chair-stand tests(CST). Anthropometric measurementswere recorded for all participants, allowing for the calculation of body mass index(BMI), waist-to-hip ratio(WHR), and appendicular skeletal muscle mass index(ASMI). Additionally, IL6 and IL10levels were estimated using Sandwich-ELISA. Results: Among the 130participants, 33 were free from sarcopenia, 35 exhibited pre-sarcopenia, 29 had sarcopenia, and 33 presented severe-sarcopenia. A majority (63 %) of the participants were male, and a substantial portion (77 %) had both diabetes and sarcopenia. The study's findings revealed that the SARCCalF questionnaire demonstrated a lower mean score in the non-sarcopenia group, with an increasing trend from pre-sarcopenia to severe-sarcopenia groups. HGS, CST results, and ASMI exhibited a reverse trend. Post-Hoc Tukey's tests revealed that IL6, IL10, IL6:IL10, and Calf Circumference(CC) exhibited significant differences between the study groups. Furthermore, ROC analysis demonstrated that IL6, IL10, IL6:IL10, and CC possessed an AUC ranging between 0.7 and 0.9, showcasing good sensitivity and specificity in distinguishing between non-sarcopenia and pre-sarcopenia. Conclusion: This study highlights the utility of IL6, IL10, IL6:IL10, and CC in the early identification of pre-sarcopenia among older individuals, offering valuable insights for clinicians to intervene promptly and enhance their quality of life. |
| format | Article |
| id | doaj-art-cdb236ab1a5544d68b14a93cf3ad45cc |
| institution | Kabale University |
| issn | 2950-3078 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Archives of Gerontology and Geriatrics Plus |
| spelling | doaj-art-cdb236ab1a5544d68b14a93cf3ad45cc2024-11-23T06:36:15ZengElsevierArchives of Gerontology and Geriatrics Plus2950-30782024-09-0113100046Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of SarcopeniaSharon P Rose0Anju Srinivas1Akila Prashant2Prathiba Periera3Suma M Nataraj4Kusuma K Shivashankar5Dept of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, IndiaDept of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, IndiaDept of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, IndiaDept of Geriatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, IndiaDept of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, IndiaDept of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India; Corresponding author at: Associate Professor, Dept of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India.Background: This study aims to investigate the levels of interleukin6(IL6), interleukin 10(IL10), the IL6:IL10 ratio, and various anthropometric measurements in different stages of sarcopenia among older individuals. Methodology: Conducted as a one-year cross-sectional study using purposive sampling, involving individuals aged 58–85 years, screened for sarcopenia based on the AWGS-2019 criteria. Case-finding methods included the SARCCalF questionnaire, handgrip strength(HGS), and chair-stand tests(CST). Anthropometric measurementswere recorded for all participants, allowing for the calculation of body mass index(BMI), waist-to-hip ratio(WHR), and appendicular skeletal muscle mass index(ASMI). Additionally, IL6 and IL10levels were estimated using Sandwich-ELISA. Results: Among the 130participants, 33 were free from sarcopenia, 35 exhibited pre-sarcopenia, 29 had sarcopenia, and 33 presented severe-sarcopenia. A majority (63 %) of the participants were male, and a substantial portion (77 %) had both diabetes and sarcopenia. The study's findings revealed that the SARCCalF questionnaire demonstrated a lower mean score in the non-sarcopenia group, with an increasing trend from pre-sarcopenia to severe-sarcopenia groups. HGS, CST results, and ASMI exhibited a reverse trend. Post-Hoc Tukey's tests revealed that IL6, IL10, IL6:IL10, and Calf Circumference(CC) exhibited significant differences between the study groups. Furthermore, ROC analysis demonstrated that IL6, IL10, IL6:IL10, and CC possessed an AUC ranging between 0.7 and 0.9, showcasing good sensitivity and specificity in distinguishing between non-sarcopenia and pre-sarcopenia. Conclusion: This study highlights the utility of IL6, IL10, IL6:IL10, and CC in the early identification of pre-sarcopenia among older individuals, offering valuable insights for clinicians to intervene promptly and enhance their quality of life.http://www.sciencedirect.com/science/article/pii/S2950307824000432SarcopeniaHand grip strengthSarc-calf questionnaireIL6IL10Sarcopenic Obesity |
| spellingShingle | Sharon P Rose Anju Srinivas Akila Prashant Prathiba Periera Suma M Nataraj Kusuma K Shivashankar Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia Archives of Gerontology and Geriatrics Plus Sarcopenia Hand grip strength Sarc-calf questionnaire IL6 IL10 Sarcopenic Obesity |
| title | Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia |
| title_full | Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia |
| title_fullStr | Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia |
| title_full_unstemmed | Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia |
| title_short | Inflammation, muscle health and aging: Calf circumference as a cost-effective diagnostic indicator of Sarcopenia |
| title_sort | inflammation muscle health and aging calf circumference as a cost effective diagnostic indicator of sarcopenia |
| topic | Sarcopenia Hand grip strength Sarc-calf questionnaire IL6 IL10 Sarcopenic Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2950307824000432 |
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