Sex hormones and immune regulation in ovarian cancer
Abstract Ovarian cancer continues to be a major cause of morbidity and mortality in women, with immune regulation playing a critical role in its progression and treatment response. This review explores the interplay between sex hormones, particularly estrogen and progesterone, and immune regulation...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01675-w |
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| _version_ | 1841559394833137664 |
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| author | Rui Zhao Wenqin Lian Qiong Xu |
| author_facet | Rui Zhao Wenqin Lian Qiong Xu |
| author_sort | Rui Zhao |
| collection | DOAJ |
| description | Abstract Ovarian cancer continues to be a major cause of morbidity and mortality in women, with immune regulation playing a critical role in its progression and treatment response. This review explores the interplay between sex hormones, particularly estrogen and progesterone, and immune regulation in ovarian cancer. We delve into the mechanisms by which these hormones influence immune cell function, modulate immune checkpoints, and alter the tumor microenvironment. Key pathways involving estrogen and progesterone receptors are examined, highlighting their impact on tumor growth and immune evasion. The review also discusses the therapeutic implications of these interactions, including the potential for combining hormone-based therapies with immune checkpoint inhibitors. Personalized medicine approaches, leveraging biomarkers for predicting treatment response, are considered essential for optimizing patient outcomes. Finally, we address current research gaps and future directions, emphasizing the need for advanced research technologies and novel therapeutic strategies to improve the treatment of ovarian cancer through a better understanding of hormone-immune interactions. |
| format | Article |
| id | doaj-art-cdb032cac56149169753057b989dde84 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-cdb032cac56149169753057b989dde842025-01-05T12:34:19ZengSpringerDiscover Oncology2730-60112024-12-0115111110.1007/s12672-024-01675-wSex hormones and immune regulation in ovarian cancerRui Zhao0Wenqin Lian1Qiong Xu2Department of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityAbstract Ovarian cancer continues to be a major cause of morbidity and mortality in women, with immune regulation playing a critical role in its progression and treatment response. This review explores the interplay between sex hormones, particularly estrogen and progesterone, and immune regulation in ovarian cancer. We delve into the mechanisms by which these hormones influence immune cell function, modulate immune checkpoints, and alter the tumor microenvironment. Key pathways involving estrogen and progesterone receptors are examined, highlighting their impact on tumor growth and immune evasion. The review also discusses the therapeutic implications of these interactions, including the potential for combining hormone-based therapies with immune checkpoint inhibitors. Personalized medicine approaches, leveraging biomarkers for predicting treatment response, are considered essential for optimizing patient outcomes. Finally, we address current research gaps and future directions, emphasizing the need for advanced research technologies and novel therapeutic strategies to improve the treatment of ovarian cancer through a better understanding of hormone-immune interactions.https://doi.org/10.1007/s12672-024-01675-wOvarian cancerSex hormonesEstrogenProgesteroneImmune regulation |
| spellingShingle | Rui Zhao Wenqin Lian Qiong Xu Sex hormones and immune regulation in ovarian cancer Discover Oncology Ovarian cancer Sex hormones Estrogen Progesterone Immune regulation |
| title | Sex hormones and immune regulation in ovarian cancer |
| title_full | Sex hormones and immune regulation in ovarian cancer |
| title_fullStr | Sex hormones and immune regulation in ovarian cancer |
| title_full_unstemmed | Sex hormones and immune regulation in ovarian cancer |
| title_short | Sex hormones and immune regulation in ovarian cancer |
| title_sort | sex hormones and immune regulation in ovarian cancer |
| topic | Ovarian cancer Sex hormones Estrogen Progesterone Immune regulation |
| url | https://doi.org/10.1007/s12672-024-01675-w |
| work_keys_str_mv | AT ruizhao sexhormonesandimmuneregulationinovariancancer AT wenqinlian sexhormonesandimmuneregulationinovariancancer AT qiongxu sexhormonesandimmuneregulationinovariancancer |